Diseases and Zoonosis (Type 3 Hypersensitivity and Diseases)

What is a type 3 hypersensitivity?

antibodies attack the connections between the cells

What is type 3 hypersensitivity governed by?

B cells

What is the pathogenesis pemphigus foliaceus?

blisters due to fluid filling the empty space created from the antibodies

What are signs of pemphigus foliaceus?

blisters, scabs, alopecia around the face, ears, and paws, and chapped lips effect

What is dx of pemphigus foliaceus?

send off biopsy of affected and healthy tissues

What is tx of pemphigus foliaceus?

glucocorticoids, cyclophosphamide, and azathioprine

What is prevention/control of pemphigus foliaceus?

spay/neuter

What is the prognosis for pemphigus foliaceus?

poor long-term

What is the purpose of the tx for pemphigus foliaceus?

maintenance

Pemphigus foliaceus is better than pemphigus vulgaris. Why?

vulgaris is also IN THE MOUTH

Since P vulgaris is in the mouth, what does this mean?

Pts can't eat comfortably

Bullous Pemphigoid is similar to foliaceus and vulgaris, what is the main difference?

blisters look like scald from hot water on the abdomen

The tx for bullous pemphigoid is different, what is the treatment?

Glucocorticoids and azathioprine

Bullous Pemphigoid is ____ to dx than the other two.

harder

What is systemic lupus erythematosus?

antibodies destroy RBCs, platelets, lymphocytes, clotting factors, and immunoglobulins

Systemic lupus erythematosus is partially what two things?

IMHA and IMTP

What are signs of systemic lupus erythemtosus?

synovitis, lesions in mouth, myositis, and meningitis

What is dx for systemic lupus erythematosus?

send blood off for antinuclear antibodies (ANA), SLE cells will only be seen

What is tx for systemic lupus erythematosus?

glucocorticoids, cyclophosphamide, and azathioprine

What is the prognosis for SLE?

poor

P rarely go into ____ and tx is simply ___.

remission, QOL