Whats and Hows of Mechanisms of Gene Regulation

chromatin remodeling, what

change in ability of transcription machinery to access the DNA

chromatin remodeling, how

modifying histone tails or methylation of CpGs

transcriptional regulation, what

change in how much transcription occurs at a gene

transcriptional regulation, how

regulatory transcription factors binding to promoters, enhancers, silencers

mRNA processing, what

creating different proteins from the same gene

mRNA processing, how

alternative splicing of mRNA precursors

mRNA stability, what

the longer an unstable mRNA stays in the cytoplasm, the more protein will be made

mRNA stability, how

RNA binding proteins and destroying mRNAs with microRNAs

translational regulation, what

change in how much translation occurs from an mRNA transcript

translational regulation, how

RNA binding proteins bind to mRNA to increase/decrease the activity of the ribosome during initiation

post-translational modifications, what

activating proteins that have already been made

post-translation modifications, how

phosphorylation

6 mechanisms of gene regulation in eukaryotes

1) chromatin remodeling

2) transcriptional regulation

3) mRNA processing

4) mRNA stability

5) translational regulation

6) post-translational modification