Vesicle Coating and Transport

What is the main purpose of vesicle coating in cells?

helps shape the vesicle and select specific cargo for transport between organelles.

What are the three main types of vesicle coats?

COPI, COPII, and clathrin.

What does COPII do?

coats vesicles that move materials from the endoplasmic reticulum (ER) to the Golgi apparatus (ER → Golgi).

What does COPI do?

coats vesicles that move materials backward from the Golgi to the ER or between Golgi cisternae (retrograde transport).

What does clathrin do?

coats vesicles involved in transport between the Golgi and plasma membrane, including endocytosis and exocytosis.

How does clathrin-mediated endocytosis work?

forms a lattice on the cytosolic side of the plasma membrane, shaping it into a vesicle that pinches off to bring material into the cell.

How does clathrin help in exocytosis?

It assists in sorting and forming vesicles at the trans-Golgi network that deliver materials to the plasma membrane or endosomes.