GN 301 Homework 7

A mutation in which one base pair is substituted for another base pair without increasing or decreasing the length of the DNA is called a ___ mutation.

point

The coding strand of a normal and a mutant DNA sequence are shown below:

Normal:  5’ – T T A A T G G C C A A T G A C T A C T G A A A – 3’

Mutant: 5’ –  T T A A T G G C C A A T G A T T A C T G A A A – 3’

 

The mutation can be described as a ____ (1) mutation

\
The mutation can be described as a(n) ________ (2)

\
Give the one letter abbreviation for the amino acids in the normal sequence. Write only the abbreviations for the amino acids from amino to carboxyl end and do not put any spaces between the letters so Moodle will grade it properly.

_____ (3)

\
Give the one letter abbreviation for the amino acids in the mutant sequence. Write only the abbreviations for the amino acids from amino to carboxyl end and do not put any spaces between the letters so Moodle will grade it properly.

_____ (4)

\
This can best be described as a:

_____ (5)

1. point
2. transition (C to T)
3. NORMAL IN RNA FORM:

* U U A ==A U G== ==G C C== ==A A U== ==G A C== ==U A C== ==U G A== A A
* MANDY


4. MUTANT IN RNA FORM:

* U U A ==A U G== ==G C C== ==A A U== ==G A U== ==U A C== ==U G A== A A
* MANDY


5. silent mutation

The coding strand of a normal and a mutant DNA sequence are shown below:

Normal:  5’ – C G G A T G G C G C G T T G A A C G T A T T A A A T A A G C – 3’

Mutant:  5’ – C G G A T G G C G G T T G A A C G T A T T A A A T A A G C – 3’

The mutation can be described as a _____ mutation

The mutation can be described as a(n) ______

Give the one letter abbreviation for the amino acids in the normal sequence. Write only the abbreviations for the amino acids from amino to carboxyl end and do not put any spaces between the letters so Moodle will grade it properly.

_________

 Give the one letter abbreviation for the amino acids in the mutant sequence. Write only the abbreviations for the amino acids from amino to carboxyl end and do not put any spaces between the letters so Moodle will grade it properly.

______

At the protein level, this mutation can best be described as a ___________

1. frameshift
2. deletion
3. NORMAL SEQUENCE IN RNA FORM:
* C G G ==A U G== ==G C G== ==C G U== ^^U G A^^ A C G U A U U A A A U A A G C
* MAR
4. MUTANT SEQUENCE IN RNA FORM:
* C G G @@A U G@@ @@G C G@@ @@G U U@@ @@G A A@@ @@C G U@@ @@A U U@@ @@A A A@@ @@U A A@@ G C
* MAVERIK
5. readthrough

Approximately ____ % of miscarried fetuses have a chromosome disorder.

50

Exposure to radiation is measured in units called _____. These units are abbreviated with as "Sv".

sieverts

In a one year period, the average person in the USA receives a radiation dose of approximately

6\.2 msv

A test called the ____ Test mixes a chemical, liver extract, and bacteria to determine if the chemical causes mutations.

Ames test

Responsible for Familial Down Syndrome

Robertsonian translocation

Responsible for Burkitt's Lymphoma

reciprocal translocation

Responsible for Turner Syndrome

monosomic

Responsible for Charcot Marie Tooth Disease

duplication

Responsible for Cri du Chat

deletion

A ___ condition exists when the individual has a chromosome number that is not an exact multiple of the haploid chromosome number for that species.

Aneuploid

A mutation that inserts a base pair into the DNA within a gene resulting in an alteration of the reading frame for protein production is called a ___ mutation.

frameshift

The coding strand of a normal and a mutant DNA sequence are shown below:

Normal:  5’ –  C C A A T G A T T A A C A C G T A T T A G A A – 3’

Mutant: 5’ –  C C A A T G A T T A A T A C G T A T T A G A A  – 3’

 

The mutation can be described as a _________

The mutation can be described as a(n) _______

Give the one letter abbreviation for the amino acids in the normal sequence. Write only the abbreviations for the amino acids from amino to carboxyl end and do not put any spaces between the letters so Moodle will grade it properly.

_______-

 Give the one letter abbreviation for the amino acids in the mutant sequence. Write only the abbreviations for the amino acids from amino to carboxyl end and do not put any spaces between the letters so Moodle will grade it properly.

______

At the protein level, this mutation can best be described as a

_________

\n

1. point
2. transversion (c to t, pyramidine to pyramidine)
3. NORMAL IN RNA FORM
* C C A @@A U G@@ @@A U U@@ @@A A C@@ @@A C G@@ @@U A U@@ @@U A G@@ A A
* MINTY
4. MUTANT IN RNA FORM
* C C A @@A U G@@ @@A U U@@ @@A A U@@ @@A C G@@ @@U A U@@ @@U A G@@ A A
* MINTY
5. Silent

The coding strand of a normal and a mutant DNA sequence are shown below:

Normal:  5’ – C G G A T G G C G G T T G A A C G T A T T A A A T A A G C – 3’

Mutant:  5’ – C G G A T G G C G C G T T G A A C G T A T T A A A T A A G C – 3’

 

The mutation can be described as a __________

The mutation can be described as a(n) ________

Give the one letter abbreviation for the amino acids in the normal sequence. Write only the abbreviations for the amino acids from amino to carboxyl end and do not put any spaces between the letters so Moodle will grade it properly.

_______

 Give the one letter abbreviation for the amino acids in the mutant sequence. Write only the abbreviations for the amino acids from amino to carboxyl end and do not put any spaces between the letters so Moodle will grade it properly.

____

At the protein level, this mutation can best be described as a

_______

1. frameshift
2. insertion
3. NORMAL IN RNA FORM
* C G G @@A U G@@ @@G C G@@ @@G U U@@ @@G A A@@ @@C G U@@ @@A U U@@ @@A A A@@ @@U A A@@ G C
* MAVERIK
4. MUTANT IN RNA FORM
* C G G ==A U G== ==G C G== ==C G U== ^^U G A^^ A C G U A U U A A A U A A G C
* MAR
5. nonsense mutation

Approximately ___ % of pregnancies spontaneously miscarry.

15

A ___ condition exists when an organism has more than two copies of each chromosome type.

polyploid