Lipid Metabolism 3 (2)

Amphipathic:

Has both hydrophilic and hydrophobic property

Phosphatidic acid

inorganic phosphate attached to a triglyceride

glycero-phospholipids

Add alcohols to phosphatidic acid

Phosphatidyl choline: hydrophilicity?

hydrophoic and hydrophilic

mixed micelle

With more than one type of amphipathic molecules

Pseudomicelle

With a nonpolar substance dissolved in the center region

Mixed pseudomicelle

having the property of both mixed and pseudo micelle

having more than one type of amphipathic molecules and with a nonpolar substance

what is hydrophobicity of triglyceride (TG) and cholesterol ester (CE)

TOTALLY HYDROPHOBIC

picture is of cholesteryl ester

What do all serum lipoproteins have in common?

1) All transport lipid
2) all are mixed pseudo-micelles
-have phopholipids, cholesterol, and fatty acid sheels with TG and CE (cholesterol ester) in middle
3) Made up of both lipid and protein
-non-covalent interactions

What type of interactions occurs within all serum lipoproteins

Non-covalent interactions (interactions between lipid and protein)

All serum lipoproteins are pseudo-micelles.
-the shell is made up of what?
-core is made up of what?

shell= phospholipids, cholesterol, and fatty acids
core= TG and CE (cholesterol ester)

the 3 difference among serum lipoproteins

1) content of core--TG rich vs cholesterol-rich
2) Types of apolioproteins (marker of lipoproteins)
3) Type of lipid carried
-endogenous (liver-made) lipid OR
-exogenous (dietary) lipid

liporprotein carrier of TG

VLDL (very low density lipoprotein)

Relative size and density of lipoproteins

chylomicrons- largest by far (1000-5000), lowest density--highest proportion of lipids and least proportion of proteins)
-VLDL
-LDL
-HDL

Which lipoproteins are rich in TG (triglycerides)?

-chylomicrons
-VLDL (very low density lipoprotein)
-IDL (Intermediate-density lipoprotein)

Which lipoproteins are rich in CE (cholesterol ester) ?

-LDL (low density lipoprotein)
-HDL (high desnity lipoprotein)

Chylomicrons are assembled in intestinal mucosal cells and carry what souce of TAG (triacylglycerol)?

dietary (exogenous)

Electrophoresis pattern
of fasting plasma

the primary indicator for fasting is chylomicrons, means didn't eat fatty acids)
If dont see VLDL (means didn't supply glucose)

Electrophoresis pattern
of FED plasma

see all 4 lipoproteins

cholesteryl ester

cholesterol with a FA esterified to it