HF Dosing (QD and target)

Captopril

Daily: 6.25mg TID

Target: 50mg TID

Enalapril

Daily: 2.5mg BID

Target: 10-20mg BID

Fosinopril

Daily: 5-10mg QD

Target: 40mg QD

Lisinopril

Daily: 2.5-5mg QD

Target: 20-40mg QD

Perindopril

Daily: 2mg QD

Target: 8-16mg QD

Quinapril

Daily: 5mg BID

Target: 20mg BID

Ramipril

Daily: 1.25-2.5 mg QD

Target: 10mg QD

Trandolapril

Daily: 1mg QD

Target: 4mg QD

Candesartan

Daily: 4-8mg QD

Target: 32mg QD

Losartan

Daily: 25-50mg QD

Target: 50-150mg QD

Valsartan

Daily: 20-40mg QD

Target: 160mg BID

Sacubitril-valsartan

Daily: 49mg/51mg BID

Initial: 24mg/26mg BID

Target: 97mg/103mg BID

Bisoprolol

Daily: 1.25mg QD

Target: 10mg QD

Carvedilol

Daily: 3.125mg BID

Target: 25-50mg BID

Carvedilol CR

Daily: 10mg QD

Target: 80mg QD

Metoprolol succinate ER (CR/XL)

Daily: 12.5-25mg QD

Target: 200mg QD

Spironolactone

Daily: 12.5-25mg QD

Target: 25-50 mg QD

Eplerenone

Daily: 25mg QD

Target: 50mg QD

Dapagliflozin

Daily: 10mg QD

Target: 10mg QD

Empagliflozin

Daily: 10mg QD

Target: 10mg QD

Isosorbide dinitrate-hydralazine (fixed dose combo)

Daily: 20mg iso and 37.5mg hydralazine TID

Target: 40mg iso and 75mg hydralazine TID

Isosorbide dinitrate-hydralazine

Daily: 20-30 iso and 25-50mg hydralazine TID-QID

Target: 120mg iso total daily in divided doses and 300mg hydralazine total daily in divided doses

Ivabradine

Daily: 5mg BID

Target: 7.5mg BID

Vericiguat

Daily: 2.5mg QD

Target: 10mg QD

Digoxin

Daily: 0.125-0.25 mg QD

Target: Individualized variable dose

What are the I(f) channel inhibitors?

ivabradine

What are the soluble guanylate cyclase stimulators?

• vericiguat

• digoxin

What are the mineralocorticoid receptor antagonists?

• spironolactone

• eplerenone

Bumetanide

Initial daily: 0.5-1.0 mg QD or BID

Max daily: 10mg

Furosemide

Initial daily: 20-40mg QD or BID

Max daily: 600mg

Torsemide

Initial daily: 10-20mg QD

Max daily: 200mg

Metolazone

Initial daily: 2.5mg QD

Max daily: 20mg