PDTI Quiz 8/9

Which of the following statements are TRUE?

I. Infants have reduced skeletal-muscle blood flow.

II. Frequent feeding with milk doesn't influence gastric pH.

III. Infants have slower gastric emptying time than adults.

IV. 4 to 6 month old infants already develop the same metabolic capacity as adults.

a. II and III

b. I and IV

c. I and III

d. I, III and IV

c. I and III

Newborns have higher protein binding and volume of distribution, which is why they have a lower

peak concentration compared to adults.

True or False?

False

A patient weighs 90 kg; what will be the estimated body surface area?

a. 1.45 m2

b. 2.06 m2

c. 3.15 m2

d. 4.34 m2

b. 2.06 m2

What is the usual GFR range in neonates?

a. 15-60 ml/min

b. 60-100 ml/min

c. 100-150 ml/min

d. 120-140 ml/min

e. 150 ml/min

a. 15-60 ml/min

Elderly patients show prolonged gastric emptying time, more fat tissue, and decreased total body

water.

True or False?

True

Urine from patient JB has been collected for 8 hours, and a total of 800 mg creatinine has been

measured. The serum creatinine level is 0.01mg/mL. What will be the creatinine clearance in this

patient?

a. 166 mL/min

b. 166 mL/hr

c. 166 mg/mL

d. None of the above

a. 166 mL/min

Which of the following pharmacokinetic processes may be different in special patient populations

such as pediatrics or geriatrics as compared to adults?

a. Absorption

b. Distribution

c. Metabolism

d. Elimination

e. All of the above

e. All of the above

Which of the following parameters is not needed for calculating the creatinine clearance using the

Cockcroft-Gault method?

a. age

b. gender

c. height

d. weight

c. height

According to the National Kidney Foundation, a GFR of 30-59 mL/min/1.73m2 in adults indicates

stage 4 of Chronic Kidney Disease.

True or False?

False

For a high-extraction drug, if the protein binding increases, the unbound plasma concentration

remains the same.

True or False?

False

The process of drug disposition in the elderly remains the same as compared to a 25-year-old

person.

True or False?

False

Which of the following pharmacokinetic parameters would likely be different in newborns from

corresponding values in adults?

a. Total AUC

b. Elimination and rate constant (ke)

c. a and b

d. none of the above

c. a and b

Assuming that the weight-proportional dosing regimen is therapeutically sufficient for a drug,

please calculate dose for a 15 kg-child if the adult dosing regimen is 4 mg/kg BID.

a. 80 mg BID

b. 60 mg BID

c. 100 mg BID

d. 120 mg BID

b. 60 mg BID

Which of the following weights must be used while calculating dose of an aminoglycoside for an

obese patient?

a. actual body weight

b. ideal body weight

c. adjusted body weight

d. does not matter

c. adjusted body weight

Aging can only impact pharmacokinetic properties of the drug (what body does to the drug);

pharmacodynamics (effect of drug on body) remain unaltered.

True or False?

False

Which of the following is not considered a decreased function allele for SLCO1B1?

a. *5

b. *14

c. *15

d. *17

b. *14

Which of the following statins would have the least variability in AUC in patients with the

SLCO1B1 c.521CC genotype?

a.Simvastatin

b. Atorvastatin

c. Rosuvastatin

d. Fluvastatin

d. Fluvastatin

Which of the following will not significantly affect P-gp function?

a. ABCB1*1

b. Verapamil

c. St. John's Wort

d. None

a. ABCB1*1

Which of the following do you consider when evaluating the potential effects of transporter

polymorphisms on drug disposition?

a. Location

b. Transporter Function

c. Substrates

d. All of the above

d. All of the above

Select the INCORRECT statement regarding SLCO1B1.

a. Statins are dependent on OATP1B1 for uptake into hepatocytes.

b. Patients with the c.521CC genotype are at increased risk of simvastatin-associated myopathy.

c. SLCO1B1 is the only gene to consider when dosing rosuvastatin.

d. *5 homozygous carriers have a greater pharmacodynamic response to repaglinide.

c. SLCO1B1 is the only gene to consider when dosing rosuvastatin.