[M1] Medicinal Organic Chemistry Pool '24 - '25

Ascorbic acid and tetracycline are

Enols

What are the active forms of Simvastatin and Lovastatin that can inhibit the rate-limiting step in cholesterol synthesis?

Beta-hydroxy acids

Derivatives of benzylsulfonylureas are

Oral hypoglycemics

The functional group of codeine and scopolamine is a/an

Esters

Functional group of Bupivacaine

Amines

Procaine is a/an

Esters

The general formula C_nH_2nO can be assigned to a saturated

Aldehyde

1,3-dimethylxanthine is

Theophylline

Local anesthetic that is derivative of benzoic acid is

Procaine

Xanthine derivatives are indicated in/for

Asthma

Paracetamol is a/an

Aniline derivative

Mexiletine is what type of antiarrhythmic drug?

Xylyl derivative

Which of the following liquid anesthetics is the least volatile?

Halothane

Which of the following anesthetic is most volatile?

Diethyl ether

ln which of the following groups of drugs is the mechanism of action for diuresis associated with a free –SO₂NH₂ group?

Carbonic anhydrase inhibitor

Diphenoxylate is a structural analog of

Meperidine

The antihypertensive agent Diazoxide is most similar in chemical structure to which of the following diuretics?

Hydrochlorothiazide

All of the following anesthetics are gases at room temp, except

Halothane

The piperidine moiety of morphine is common with the following analgesics, except

Methadone

The activity of the following drugs is dependent upon a p-phenyl-N-alkylpiperidine, except

Imipramine

The following are semi-synthetic penicillins, except

Pen G

The following drug has the imidazoline nucleus, except

Phenylephrine

The deficiency of the following minerals decrease drug-metabolizing capacity, except

Iron

The optimal diuretic activity of benzothiazines on certain structural features. These include:
I. Saturation of the 3,4-double bond increases potency

II. Methyl groups at position 2 decreases potency

III. Replacement of the sulfonyl group in position 1 shortens the activity

I only

Which of the following statements concerning adrenergic agonists are true?

I. Catecholamines are activated by the methylation of the hydroxyl group

II. The ethylamine chain is essential to their activity

III. N-substituent alter drug activity

II and III

Amide type local anesthetics are

Long acting

Barbiturates containing a sulfur atom are usually

Ultra-short acting

Barbiturates containing ethyl and phenyl substitution at carbon 5 are usually

Long acting

Antibacterial potencies of primary alcohol increases with molecular weight up to ____ only

C 8

The potent vasoconstrictor Angiotensin II is a polypeptide containing how many amino acids?

8

Which of the following is least susceptible to gastric acid degradation?

I. Estolate

II. Base

III. Ethylsuccinate

I only

Which of the following agents has/have a beta-phenylethylamine structure with the phenyl moiety containing ortho-dihydroxy substitution?

I. Epinephrine

II. Ephedrine

III. Dopamine

I and III

Which of the following opioids contains a phenanthrene nucleus?

Morphine

Which of the following opioids contain a piperidine nucleus?

Meperidine

Which of the following neuromuscular blockers possesses a steroid nucleus?

Pancuronium

Which of the following metabolites of methoxyflurane is primary responsible for the nephrotoxicity associated with this inhalation anesthetic?

Fluoride

What is the most potent effect of trimethyl substitutions in positions 1, 3, and 7 of the xanthine molecules?

CNS stimulation

Which of the following drugs has the following structure: CH₃CH₂CH₂C(CH₃CH₂CH₂)HCOOH

Valproic acid

This drug is also known by the chemical name: (+)-Nalpha-dimethylphenylamine

Metamphetamine

Which functional moieties generally make up the hydrophilic center of local anesthetics?

Secondary or tertiary amines

What is the IUPAC name of Valproic acid?

2-propylpropanoic acid

What is the common functional moiety present in the molecules of the clinically useful carbonic anhydrase inhibitor?

SNO₂H₂

Which of the following compounds is a 5-sulfamoylanthranillic acid derivative?

Furosemide