vitamin_B6-2024_student_verison
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16 Terms
Vitamin B6
A water-soluble vitamin involved in various metabolic functions including amino acid metabolism, neurotransmitter synthesis, and hemoglobin formation.
PLP (Pyridoxal 5'-Phosphate)
The active form of Vitamin B6, acting as a coenzyme for more than 160 enzymes involved in amino acid metabolism.
Glycogenolysis
The process of breaking down glycogen to glucose, a key metabolic role of Vitamin B6.
Transamination
A reaction in which an amino group from one amino acid is transferred to a keto acid, forming a new amino acid, facilitated by PLP.
Decarboxylation
The removal of a carboxyl group from an amino acid, leading to the formation of amines, and is dependent on Vitamin B6.
Niacin
A vitamin that can be synthesized from the amino acid tryptophan, with Vitamin B6 playing a role in its formation.
Kynureninase
An enzyme that requires Vitamin B6 for the conversion of tryptophan to niacin.
4-Pyridoxic Acid
The main excretory product of Vitamin B6 metabolism, reflecting dietary intake.
B6 Deficiency Symptoms
Symptoms of low Vitamin B6 status include stomatitis, cheilosis, glossitis, fatigue, headache, and microcytic anemia.
Pyridoxine
One of the forms of Vitamin B6, commonly found in food sources and supplements.
Erythrocyte Aminotransferases
Enzymes in red blood cells that require Vitamin B6 coenzymes; can be indicators of B6 status.
Autoimmune Disorders
Conditions that may increase the risk of Vitamin B6 deficiency.
Riboflavin
A vitamin that works in conjunction with Vitamin B6 for certain metabolic functions.
Assessment of B6 Status
Direct methods include measuring plasma B6 levels and urinary 4-pyridoxic acid; indirect methods may include functional tests based on enzyme activity.
GABA
Gamma-aminobutyric acid, a neurotransmitter synthesized with the help of Vitamin B6.
Pharmacological Uses of Vitamin B6
Higher-than-normal doses of Vitamin B6 are used in treating premenstrual syndrome, morning sickness, depression, metabolic diseases, and carpal tunnel syndrome.