Benign prostatic hyperplasia (BPH)

Pathogenesis of BPH (2)

1. Hyperplasia in fibromuscular

   stroma

2. Hyperplasia in glandular epithelium of the transitional zone

BPH risk factors (2)

1. Age

2. Androgens

   By 80 years old, 90% of men have BPH

BPH treatment

Drug that inhibits 5 alpha reductase

Gross morphology of BPH (4)

1. Large prostate

2. Well defined nodules

3. Cystic spaces (Dialated glands)

4. Narrow prostatic urethra

Benign prostatic hyperplasia (BPH) – Clinical feature

Bladder outlet obstruction

Benign prostatic hyperplasia (BPH) – Some diagnostic tests

1. Urinalysis

   1. Eliminate suspicion of infection

2. Digital rectal exam (DRE)

   1. Typically reveals an enlarged, nontender, and symmetrical prostate