2.2 Cell Membrane

Cholesterol

Mosaic: create space between phospholipids and increase fluidity, think: small & cozy.

Peripheral

______ proteins: do not interact w hydrophobic part of bi- layer, held to surface by non- covalent bonds.

Fluid

Part of model that is not rigid, molecules are free to move.

Enzyme

Type of membrane proteins that catalyze a reaction at membrane surface.

Signal / Receptor

Type of membrane proteins that sit on exterior of the membrane until something interesting comes by and lunges at it, causes biochemical cascade → chain of reaction (guards reacting at intruder /passerby)

Saturation

Factor that affects fluidity, fatty acids on the phospholipids.

Mosaic

Part of model that is composed of many diff molecules

Phospholipids

Mosaic: arranged in a bi- layer due amphiphilic nature, may have attached carbs that function in the region: glyco- lipid.

Protects

Role of membrane that _________, from pH, salinity, temperature, etc

Compartmentalization

Role of membrane, separating functions

Proteins

Mosaic: adds function, surface or transmembrane

Transport

Type of membrane proteins that move materials across the membrane

Attachment & Recognition (Anchor)

Membrane protein that has an attachment point for cytoskeleton of other cells or recognition of chemical environment, blood recognizers

Integral

_______ protein: impeded in bi-layer, has hydrophobic region to interact w interior of bi-layer, transmembrane (mostly)

Examples of peripheral membrane proteins:

microtubules, microfilaments & intermediate filaments

Filter

Role of membrane in cell, sieve

Temperature

Factor affecting the fluidity of a molecule

Glyco-lipid

lipids that are generally found on the extracellular face of cellular membranes

Glyco-protein

proteins that are generally found on the extracellular face of cellular membranes

biochemical cascade

chain of reactions

Bacterial infection in the lungs

typical symptom of cystic fibrosis

10 nm

How thick is the lipid bilayer