normoblastic maturation

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Last updated 8:23 PM on 9/2/26
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7 Terms

1
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normoblastic maturation in order

  1. pronormoblast (rubriblast)

  2. basophilic normoblast (prorubricyte)

  3. polychromatophilic normoblast (rubricyte)

  4. orthochromic normoblast (metarubricyte)

  5. reticulocyte (diffusely basophilic erythrocyte)

  6. RBC (erythrocyte)


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pronormoblast (rubriblast)

round, primitive nucleus, centrally located with one or more nucleoli. delicate chromatin w/ no clumping. dark blue nucleus. cytoplasm royal blue and abundant. </= 1% in bone marrow.

<p>round, primitive nucleus, centrally located with one or more nucleoli. delicate chromatin w/ no clumping. dark blue nucleus. cytoplasm royal blue and abundant. &lt;/= 1% in bone marrow.</p>
3
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basophilic normoblast (prorubricyte)

chromatin beginning to condense, nucleoli indistinct or not visible. cytoplasm more abundant & deeply basophilic. 1-3% in bone marrow

<p>chromatin beginning to condense, nucleoli indistinct or not visible. cytoplasm more abundant &amp; deeply basophilic. 1-3% in bone marrow</p>
4
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polychromatophilic normoblast (rubricyte)

thickened chromatin that is irregularly condensed, no visible nucleoli. gray-blue cytoplasm with tinge of pink. 13-30% in bone marrow, last stage capable of mitosis.

<p>thickened chromatin that is irregularly condensed, no visible nucleoli. gray-blue cytoplasm with tinge of pink. 13-30% in bone marrow, last stage capable of mitosis.</p>
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orthochromic normoblast (metarubricyte)

heavily condensed chromatin that is solid black/blue and degenerated. nucleus ¼ the volume of cell, ready to be extruded from cell. cytoplasm predominantly pink w/ blue background. 1-4% in bone marrow

<p>heavily condensed chromatin that is solid black/blue and degenerated. nucleus ¼ the volume of cell, ready to be extruded from cell. cytoplasm predominantly pink w/ blue background. 1-4% in bone marrow</p>
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reticulocyte (diffusely basophilic erythrocyte)

anucleate. red cytoplasm with tinge of blue. 0.5-1.5% in blood of adults, 0.5-4% in blood of children. abundant in bone marrow but not counted b/c no nucleus

<p>anucleate. red cytoplasm with tinge of blue. 0.5-1.5% in blood of adults, 0.5-4% in blood of children. abundant in bone marrow but not counted b/c no nucleus</p>
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RBC (erythrocyte)

orange/red cytoplasm. abundant in bone marrow but not counted b/c anucleate. biconcave disc with central pallor. deformability essential to prevent rupture when navigating microvascular. carries O2, CO2, and H ions.

<p>orange/red cytoplasm. abundant in bone marrow but not counted b/c anucleate. biconcave disc with central pallor. deformability essential to prevent rupture when navigating microvascular. carries O2, CO2, and H ions.</p>