Glucocorticoid Agents (Corticosteroids)

Action:

• provide hormonal, anti-inflammatory, and metabolic effects including suppression of articular and systemic diseases

• reduce inflammation in chronic conditions that can damage healthy tissue through a series of reactions

Indications:

• replacement therapy for endocrine dysfunction

• anti-inflammatory and immunosuppressive effects

• treatment of rheumatic, respiratory, and various other disorders

Side effects:

• muscle atrophy

• gastrointestinal distress

• glaucoma

• adrenocortical suppression

• drug-induced Cushing syndrome

• weakening with breakdown of supporting tissues

• mood changes

• hypertension

Implications for PT:

• therapist must wear mask when working with patient on glucocorticoid therapy since their immune system is weakened

• be aware of signs of toxicity including moon face, buffalo hump, and personality changes