Death of Neutrophils and Control of Inflammation

Neutrophils secrete cytokines such as IL-1α, IL-1β, IL-1RA, TNF-α,CXCL8 (IL-8), IL-10 and transforming growth factor-β (TGF-β).

Once in tissues, neutrophils undergoapoptosis and are finally cleared throughphagocytosis by resident macrophages anddendritic cells

Senescent neutrophils in blood upregulateexpression of CXCR4, which allows them toreturn to the bone marrow for final clearance.

The clearance of apoptotic neutrophils is alsoimportant for controlling neutrophil production inthe bone marrow.

Phagocytosis of apoptotic neutrophil triggers ananti-inflammatory response characterized by areduction in IL-23 by macrophages.

Phagocytosis of apoptotic neutrophil triggers ananti-inflammatory response characterized by areduction in IL-23 by macrophages.

Less IL-23 leads to reduced IL-17 levels and toless G-CSF production, and finally, inconsequence to reduced granulopoiesis.