CHAPTER 5 BACTERIAL TRANSFORMATION & POLYMERASE CHAIN REACTION
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24 Terms
What is the clinical significance of Bacterial Transformation in Biotechnology?
it explains horizontal gene transfer responsible for rapid antibiotic resistance dissemination, enables recombinant DNA tech. for pharm prod., and provides insights into genetic engineering approaches for human gene therapy.
When did Griffith discover transformation?
1928
How did the mouse die in station 1?
it died from pneumonia due to encapsulated virulent bacteria
What did the s-strain contain?
a capsule enabling immune evasion
How was the R-strain different from the s-strain?
it lacked a capsule
What happened in station-3 of Griffith’s experiment?
a heat-killed S strain was injected into the mouse and thermal denaturation destroyed the bacterial proteins and viability so the mouse survives.
What happened in station 4?