Pharmacology Lecture 11: Acetaminophen

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Last updated 1:46 AM on 9/24/26
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12 Terms

1
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What are the two main pharmacological actions of acetaminophen?

1. Analgesic

2. Antipyretic

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Can acetaminophen reduce severe pain?

No

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Does acetaminophen have any anti-inflammatory action?

No

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How does acetaminophen reduce pain?

Activation of descending serotoninergic inhibitory pathways

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How does acetaminophen reduce inflammation?

Inhibition of hypothalamic heat-regulating center

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What is the major adverse effect of overdosing on acetaminophen?

Hepatotoxicity

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What two functions are lost with forming an active metabolite in hepatocytes?

1. Mitochondrial

2. Intracellular protein

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What is the substance that can seriously increase the hepatotoxic potential of acetaminophen?

Alcohol

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What is the most common OTC name for acetaminophen?

Tylenol

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What does aspirin affect that acetaminophen does not?

Blood clotting

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What benefit does aspirin have that acetaminophen does not?

Anti-inflammatory

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What two complications are caused by aspirin that is not caused by acetaminophen?

1. Gastrointestinal irritation

2. Reye's syndrome