Pharmacology 1: Hyperlipidemia, Hypothalamus, Pituitary Drugs for Final Exam

Atorvastatin

MOA: HMG co-reductase inhibitor (long acting) Use: Hyperlipidemia SE: Myopathy, liver dysfunction, rhabdomyolysis; metabolized by CYP system (CYP inhibitors can increase concentration in blood)

Simvastatin

MOA: HMG co-reductase inhibitor (lower potency)
Use: Hyperlipidemia
SE: Myopathy, liver dysfunction, rhabdomyolysis; metabolized by CYP system (CYP inhibitors can increase concentration in blood

Cosyntropin

MOA: Synthetic formulation of ACTH
Use: Distinguish congenital adrenal hyperplasia (CAH) from ovarian hyperandrogenism; diagnose adrenal insufficiency
SE: Not used therapeutically, only for diagnostic purposes

Desmopressin

MOA: Long-acting synthetic analog of vasopressin; acts on V1 receptors in vascular smooth muscle to cause vasoconstriction; acts on V2 receptors in kidneys to increase water reabsorption by causing insertion of aquaporin channels
Use: Treatment of nocturnal enuresis; treatment of diabetes insipidus; can be used to control bleeding
SE: Used with caution in patients with coronary artery disease

Conivaptan

MOA: Dual vasopressin antagonist at V1 and V2 receptors
Use: Treatment of euvolemic and hypervolemia hyponatremia

Tolvaptan

MOA: Selective vasopressin antagonist at V2 receptors
Use: Treatment of euvolemic and hypervolemia hyponatremia; treatment of SIADH (Syndrome of inappropriate anti-diuretic hormone