Pharmacology 1: Cholinergic Drugs for Final Exam

Glycopyrolate

MOA: Muscarinic antagonist
Use: Reduces salivary gland activity
SE: Antimuscarinic (anticholinergic) side effects

Pralidoxime

MOA: Binds to cholinesterase and removes organophosphate, reactivating the enzyme
Use: Treatment for organophosphate poisoning

Bethanechol

MOA: Muscarinic agonist
Use: Treats urinary retention by acting on bladder

Oxybutynin

MOA: Muscarinic antagonist
Use: Reduces overactive bladder
SE: Antimuscarinic (anticholinergic) side effects

Edrophonium

MOA: Acetylcholinesterase inhibitor acting primarily on skeletal muscle
Use: Treatment and diagnostic test for myasthenia gravis; reversal agent for non-depolarizing neuromuscular blockers
SE: Cholinergic side effects when given in excess

Donepezil

MOA: Acetylcholinesterase inhibitor acting primarily in the CNS
Use: Alzheimer's disease
SE: Cholinergic side effects

Atropine

MOA: Muscarinic antagonist at heart and other target organs
Use: Treatment for bradycardia; treats parasympathetic symptoms of organophosphate poisoning
SE: Anticholinergic side effects

Pancuronium

MOA: Non-depolarizing neuromuscular blocker (competitive antagonist at nicotinic receptors)
Use: Skeletal muscle relaxation during surgery or mechanical ventilation
SE: Effects can be reversed by acetylcholinesterase inhibitors

Succinylcholine

MOA: Depolarizing neuromuscular blocker at nicotinic receptors causing persistent depolarization and muscle paralysis
Use: Skeletal muscle relaxation during surgery or mechanical ventilation
SE: Effects cannot be reversed by acetylcholinesterase inhibitor