Rheumatology

important autoantibodies

initial screening test for SLE →

confirmatory →

Anti Nuclear Antibody (ANA)

Anti-dsDNA

systemic lupus erythematosus (SLE)

_____system, _______ disorder, presents in _________, more common in _______ and ________ origin.

general features (5), skin (4), musculoskeletal (2), cardio (2), respiratory (2), renal (2), neuro (3)

SLE (ANA, ANCA, ESR, initial and confirmatory test)

anti histone antibodies →

(due to ________ used for ______ along with ________)

other DX (3)

chronic fatigue syndrome

diagnosed after _____ months of fatiguability affecting mental and physical function more than ___% of time in absence of __________.

more common in M/F

no past _________ as RF

other features (9)

DX (to exclude other pathology) (12)

TX (2)

chronic fatigue syndrome

myopathies

features (3)

causes (4 subs)

polymyositis

features (2)

common in _______ muscles (6)

DX (2) confirmatory (1)

polymyalgia rheumatica (PMR) is often differentiated with _________.

important differentiating point

-creatinine kinase, esr, crp

-symptoms (2)

-sites of pain

-50% patient have…

-initial test (1)

-TX (1)

polymyositis

suspect →

polymyositis

sjogren’s syndrome is an _________ disorder affecting ___________ resulting in _________.

1ry or 2ry to ______, ______

more common in M/F

features (main 3)

SX (5)

TX (2)

likely diagnosis

likely diagnosis

systemic sclerosis (________)

etiology →

characterized by →

more common in M/F

_______ phenomenon (description and only med in UK)

limited scleroderma (crest syndrome)

affects _____ and ______ predominantly

__________ may be first sign

onset and progression

subtype : C.R.E.S.T. syndrome

scl-70 Ab

ANA

diffuse scleroderma

affects _____ and _____ predominantly

onset and progression

commonest cause of death is ______ (i.e _____ and ______)

other complication (2)

prognosis

scl-70 Ab

ANA

likely diagnosis →

limited systemic sclerosis (CREST syndrome)

temporal arteritis = ________ = _________

50% of patients with _______ have temporal arteritis

histology showing

features (7)

DX initial, confirmative + finding, normal _____ and ______

TX main, add on, kawasaki case, other add on, specialist

likely diagnosis →

initial test →

confirmative test →

TX → + if patient already commenced on it

likely diagnosis →

TX →

gout (gouty arthritis) = high _______

main features (3)

first presentation (1) commonest area (3)

risk factors (3)

question hints (3)

gout

DX main (+ if no fever)

TX acute 1st and 2nd line, long term (3)

radiological features of gout (6)

septic arthritis

monoarthritis

symptoms (5) + a RF (4)

commonly affected area (2)

commonest causative organism (1) (+ if young sexually active)

DX (2)

TX first line start when, if allergic, if causative organism, if still not responding

reactive arthritis = __________

__________ + ___________ + extraarticular features

fever, age category, typically follows (2)

extraarticular features (_______ triad) (4)

TX (3)

De Quervain’s disease

other names (3)

definition

pain elicited on ________ and on _________

DX

lateral epicondylitis

medial epicondylitis

dupuytren’s contracture

definition and cause

more common in M/F

60-70% have __________

specific causes (6)

mechanism

TX

trigger finger = _________

commonest fingers (3)

features (3)

diagnosis

De Quervain’s Tenosynovitis

diagnosis

De Quervain’s Tenosynovitis

churg strauss vs wegeners granulomatosis

other name, symptoms, DX