Kreb's Cycle

Acetyl-CoA

OAA
_____→citrate synthase→

citrate synthase

OAA
Acetyl-CoA→_____→

Citrate

Acetyl-CoA→citrate synthase→
_____

H₂O; H₂O

Citrate
(→_____)→aconitase→(_____→)

aconitase

Citrate
(→H₂O)→_____→(H₂O→)

Dehydration and hydration.

What are the two steps in aconitase?

Isocitrate

(→H₂O)→aconitase→(H₂O→)
_____

NAD⁺; NADH; CO₂

Isocitrate
_____→IDH→_____+_____

Isocitrate dehydrogenase (IDH)

Isocitrate
NAD⁺→_____→NADH+CO₂

alpha-Ketoglutarate

NAD⁺→IDH→NADH+CO₂
_____

CoASH; CO_2; NAD⁺; NADH

alpha-Ketoglutarate
(_____→_____)→alpha-KGDH→(_____→_____)

alpha-Ketoglutarate dehydrogenase (alpha-KGDH)

alpha-Ketoglutarate
(CoASH→CO₂)→_____→(NAD⁺→NADH)

Succinyl-CoA

(CoASH→CO2)→alpha-KGDH→(NAD+→NADH)
_____

ADP; P_i; ATP; CoASH

Succinyl-CoA
(_____+_____→)←→Succinyl-CoA synthetase←→_____+_____

Succinyl-CoA synthetase

Succinyl-CoA
(ADP+P_i→)←→_____←→ATP+CoASH

Succinate

(ADP+P_i→)←→Succinyl-CoA synthetase←→ATP+CoASH
_____

FAD; FADH₂

Succinate
_____←→succinate dehydrogenase←→_____

succinate dehydrogenase

Succinate
FAD←→_____←→FADH₂

Fumarate

FAD←→succinate dehydrogenase←→FADH₂
_____

fumarase

Fumarate
←→_____←→

L-Malate

←→fumarase←→
_____

NAD⁺; NADH

L-Malate
_____←→MDH←→_____

Malate dehydrogenase (MDH)

L-Malate
NAD⁺←→_____←→NADH

Oxaloacetate (OAA)

NAD⁺←→MDH←→NADH
_____

8 NADH, 2 FADH₂, 2 ATP

What are the products of the Kreb’s Cycle?