Fibric Acids - fenofibrate and gemfibrozil

triglycerides

type of fat in blood, used as energy storage molecule

-too much is bad → causes pancreatitis

PPAR-α

receptor inside cells that controls the expression of genes in lipid metabolism

fibrate pathway

fenofibrate → activates PPAR-a → increased lipoprotein lipase (LPL) and decreased ApoC-III → LPL breaks down triglycerides in triglyceride-rich particles → less triglycerides in blood

LPL (lipoprotein lipase)

enzyme that breaks down triglycerides

ApoC-III

protein that inhibits LPL, tells LPL to slow down

indications of fibrates

hyperlipidemia and hyperglyceridemia

contraindications of fibrates

gallbladder disease

ADR common of fibrates

increased transaminases (too much liver enzymes in blood)

ADR rare of fibrates

hepatotoxicity and rhabdomyolysis

counseling point of fibrates

contact doctor if muscle pain develops