Ch 3: Binding and Molecular Recognition

What is the definition of molecular recognition?

Specific complex formation between two or more molecules via noncovalent interactions.

What does molecular recognition refer to?

The ability for certain molecules to bind to one another in the face of many alternatives

What is a ligand?

A molecule or group that binds to a receptor.

Binding depends on the what of the binding partners?

concentrations

Is binding a dynamic or static process?

dynamic

Binding is a dynamic process involving what?

association and dissociation

What is L_1/2?

It reveals the concentration range of the Ligand around which the receptor makes the transition from being mostly free to mostly bound.

When the ligand concentation is L_1/2 what is the concentration of the receptor equal too?

equall to that of the receptor-ligand compex

What does is mean to say binding is a dynamic process?

Each receptor is constantly releasing one ligand molecule and

What is fractional saturation (Y)?

A measure of the fraction of a potential binding site that is occupied with ligand.