Benign Prostatic Hypertrophy

Prazosin brand name:

Minipres

Prazosin class:

2nd gen alpha blocker

Prazosin dosing for BPH:

2-10mg PO in 2-3 doses

Prazosin ADE:

orthostatic hypotension, floppy iris syndrome

Prazosin monitoring:

BP, HR

Terazosin brand name:

Tezruly

Terazosin class:

2nd gen alpha blocker

Terazosin dosing for BPH:

1-10mg PO; max 20mg

Terazosin ADE:

orthostatic hypotension, floppy iris syndrome

Terazosin monitoring:

BP, HR

Doxazosin brand name:

Cardura

Doxazosin class:

2nd gen alpha blocker

Doxazosin dosing for BPH:

1-4mg PO QD; max 8mg PO QD

Doxazosin adjustments:

use not recommended if severe hepatic impairment

Doxazosin ADE:

orthostatic hypotension, floppy iris syndrome

Doxazosin monitoring:

BP, HR

Alfuzosin brand name:

UroXatral

Alfuzosin class:

2nd gen alpha blocker

Alfuzosin dosing for BPH:

10mg PO QD

Alfuzosin adjustments:

use contraindicated if hepatic impairment

Alfuzosin ADE:

orthostatic hypotension, floppy iris syndrome, prolonged QT interval

Alfuzosin monitoring:

BP

Tamsulosin brand name:

Flomax

Tamsulosin class:

selective alpha blocker

Tamsulosin dosing for BPH:

0.4mg PO QD (take with meals)

Tamsulosin ADE:

rhinitis, HA, abnormal ejaculation, dizziness, infection, orthostatic hypotensione

Tamsulosin monitoring:

BP

Silodsin brand name:

Rapaflo

Silodsin class:

selective alpha 1 blocker

Silodsin dosing for BPH:

4mg or 8mg PO QD; target dose of 8mg PO QD; take with food

Silodosin adjustments:

CrCl: 50-30: 4mg PO QD

CrCl <30: contraindicated

Silodosin ADE:

retrograde ejaculation, dizziness, diarrhea, orthostatic hypotension, HA, nasal pharyngitis, nasal congestion

Silodosin monitoring:

BP

Finasteride brand name:

Proscar

Finasteride class:

5 alpha reductase inhibitor

Finasteride dosing for BPH:

5mg PO QD

Finasteride ADE:

erectile dysfunction, decreased libido, ejaculatory disorders, gynecomastia, nausea, abdominal pain, asthenia, dizziness, flatulence, HA, rash

Finasteride monitoring:

PSA baseline

Dutasteride brand name:

Avodart

Dutasteride class:

5 alpha reductase inhibitors

Dutasteride dosing for BPH:

0.5mg PO QD

Dutasteride ADE:

erectile dysfunction, decreased libido, ejaculatory disorders, gynecomastia, nausea, abdominal pain, asthenia, dizziness, flatulence, HA, rash

Dutasteride moniroting:

PSA baseline