Minerals - Zinc, Copper, & Iron

FSHN 3600

Minerals function

• Cofactors for protein

• Enzymatic

• Structural

• Transport

Microminerals are highly dependent on ___ ___.

transport proteins

Zn & Cu are ___ ___.

transition metals

Protein-bound Zn & Cu are ___ for absorption.

hydrolyzed

Zn deficiency can impact many pathways, what are those pathways?

• γ-glutamyl hydrolase - sec. deficiency: folate

• Alcohol dehydrogenase (ADH)

• Structural role of SOD

• CHO metabolism: PDH, LDH, Fruc-1,6-bisP

• δ-ALA-dehydratase: heme synthesis

• RAR (Zn fingers)

Cu deficiency can impact many pathways, what are those pathways?

• SOD - catalytic

• Lysal oxidase: collegen synthesis

• Dopamine hydroxylase

Zn deficiency

• Anemia

• Energy problems (gluconeogenesis)

• Poor wound healing

• Folate deficiency

• Stunted growth

• Hypogeusia: taste loss.

Genetic disorders

Acrodermititis enteropathica - ZIP1 defect

Cu deficiency

• Hypochromic anemia

• Skin depigmentation: lack of melanin

• Kinky hair syndrome

• Cu color around the eyes

Genetic disorders

Wilson’s disease: Cu accumulation in the liver - ATP7B defect

Menkes disease - ATP7A defect

Cu deficiency: not absorbed.