actin microfilaments 2

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8 Terms

1
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stress fibers

  • has myosin !!

  • cytosilic

  • bundles of contractile cables, sorta sheets

2
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filopodia

  • finger-like extensions of plasma membrane

  • used to sense extra-cellular environment

3
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lamellipodia

  • sheet bundles, mesh work that push out of the cell

  • main force of cell crawling

4
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microvilli

  • tiny, finger-like portrusions of cell

  • increase surface area of the cell

5
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what are the families of GTPases used in actin polymerization pathways

  • Rho

  • Rac

  • CDC42

6
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lamellipodia pathway

first one

  1. Rac gets activated

  2. PI-3 kinase gets activated (idc)

  1. WASp (WAVE) gets activated

  2. ARP gets activated—gives branching/branched actin web/mesh

second one

  1. Rac gets activated

  2. PAK gets activated

  3. filamin gets activated

  • gives branching/branches actin web/mesh

  1. MHC (myosin heavy chain) gets inhibited

  • myosin activity decreases—less stress fibers

7
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stress fibers pathway

  1. Rho-GTP gets activated

  2. formins get activated

  • actin bundle growth—more stress fibers

  1. Rho-kinase (ROCK) gets activated

  2. MLC (myosin light chain) gets activated

  • myosin activity increases—more stress fibers

8
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filopodia pathway

  • CDC42-GTP gets activated

  • WASp gets activated

  • fimbrin gets activated

    • super tight compaction of actin microfilaments