Compounding 1

usp

what sets the standards for compounding

simple

jsut following directions

moderate

involves specialized calculations or procedures or making a preparation that has no established stability data

complex

requires specialized training. equipment, facilities, or procedures

separated

non sterile compounding must be what from the dispensing part of the pharmacy

small volume parenteral

SVP

large volume parenteral

lvp

primary engineering control

pec

sterile hood that provides ISO 5 air for sterile compounding

laminar airflow work bench

lafw

type of sterile hood that has a parallel air strea, flow in one direction

containment pec

cpec

ventilated negative pressure chemo hood used for HDs

biological safety cabinet

bsc

chemo hood

secondary engineering control

sec

iso 7 buffer room where the sterile hood is located`

containment sec

csec

ventilated negative pressure buffer room for HDs

segrgated compounding area

sca

designated space that contains an ISO 5 hood that is not part of a cleanroom suite

compounding aseptic isolator

CAI

“glovebox” for non-HDs, a clsoed front sterile hood

compounding aseptic containment isolator

caci

“glovebox” for HDs, type of closed front PEC

restricted access barrier system

clsoed front sterile hood

-includes CAIs and CACIs

containment ventialted exposure

CVE

ventilated powder hood for non sterile products

lower

is it the lower or higher the particle count, the cleaner the air

8

the anteroom where garbing and hand washing occurs must be ISO what if it opens into a positive pressure (non sterile HD compounding)

7

the anteroom where garbing and hand washing occurs must be ISO what if it opens into a negative pressure ( sterile HD compounding)

postive

what air pressure for non hazardous compounding

negative

what air pressure for hazardous compounding

cleanroom suite

one or more sterile hoods (ISO 5 pecs) inside an iso 7 buffer room (SEC) that is entered through ant anteroom

negative

biological safety cabinets have what pressure and vertical laminar airflow

2

for sterile hazardous compounding, BSC must be what class

12

minimum air changes per hour for non sterile HDs or in a C-SCA

30

minimum air changes per hour in a sterile C SEC

-25 to -10

freezer temp for freezers only having CSPs

-50—15

freezer temp containing vaccines

30 minutes

how long for PEC or C PEC to be on before compounding can begin if it was turned off

top to bottom back to front

how to clean PEC

surfactant

this lowers the surface tension to make things more miscible

wetting agents

substances that reduce the surface tension between a liquid and a solid to permit the substance to more easily spread

emulsion

mixture of 2 or more liquids which are not able to be blended together

suspension

a solid dispersed in a liquid

levigating agents

this is used in levigation to aid in the grinding

-mineral oil or glycerin

trituration

grinding of particles wihtout the addition of a liquid

oxidation reduction, hydrolysis, photolysis

msot common chemical rxns that cause most drugs to become unstable and degrade

loses

a compound is oxidized when it gains or loses electrons

gains

a compound is reduced when it gains or loses electrons

binders

allows contects of a tablet to stick together

-provides stability and strenght

acacia, starch paste, sucrose syrup, compressible sugar

diluents

lactose, starches, calcium salts, cellulose

water, glycerin, alcohol

petrolatum, mineral oil, lanolin, waxes

these are used to bulk or make something more dilute

disintegrants

these facilitate the breakup of a tablet after oral admin

alginic acid, cellulose, polacrillin, starches

lubricants

these prevent ingredients from sticking to each other and euipment

magnesium stearate, colloidal silica, glycerin, mineral oil, talc

preservatives

do not use these in neonates

chlorhexidine, povidone iodine, BAK, sorbic acid, parabens, EDTA, thiomersal

humectants

these pull in water from the atmosphere to moisturize skin

glycerin, glycerol, propylene glycol, PEG, urea, hyaluronic acid

emulsifiers

these reduce the durface tension between 2 liquids

acacia, agar, PEG