Mechanisms of Dominant Mutations

What is haploinsufficiency?

One gene does not have enough genetic mutation to ‘override’ a bad gene.

How does increased expression of genes affect regulatory proteins?

Increased/constitutive expression/activity of genes affects other proteins, specifically regulatory proteins.

What happens when a mutant protein forms a dimer with a protein of the good allele?

The mutant protein binds to the good allele protein and eliminates it, effectively overriding its function.

In what way can a mutant protein impact a protein complex like collagen?

The mutant protein can alter the properties of the complex by being incorporated into it.