Unit 5 Prototypes

Cytarabine (ara-C) and Methotrexate

Indications: solid tumors and hematologic cancers

Adverse effects: hair loss, nausea and vomiting, Diarrhea, and myelosuppresion

Antimetabolites

Cyclophosphamide and Mechlorethamine

Indications: malignancies (solid & hematologic tumors)

Adverse effects: hemorrhagic cystitis

Contraindication: drug allergy

Alkylating agents

Doxorubicin (Adriamycin)

Indications: solid tumors and hematologic malignancies

Adverse effects: hair loss, nausea, vomiting, and myelosuppression

Contraindications: drug allergy

Anthracycline

Cyclosporine

Indications: prevention of organ rejection

Adverse effects: hypertension, tremors

Contraindication: drug allergy, hepatic or renal failure, hypertension

Diptheria, tetnus to toxoids, acellular pertussis, hepatitis b immunoglobulin, influenza, and varicella virus vaccines

Indications: prevention of illness

Adverse effects: fever, rash, soreness at injection site, urticaria, convulsions, dyspnea

Contraindications: drug allergy, eggs or yeast allergy

Antacids

Indications: heartburn

Adverse effects: diarrhea, constipation, kidney stones

Contraindications: drug allergy, renal failure, electrolyte disturbance

Famotidine (Pepcid)

Indications: GERD, Peptic ulcer disease

Adverse effects: diarrhea, nausea, abdominal cramps, headache

Contraindications: drug allergy, kidney and liver dysfunction

Omeprazole

Indications: erosive esophagitis, GERD

Adverse effects: well tolerated

Contraindications: drug allergy

Proton pump inhibitors

Sucralfate

Indications: stress ulcerations

Adverse effects: nausea, constipation, and dry mouth

Contraindications: drug allergy

Miscellaneous acid controlling drugs

Diphenoxylate with Atropine and Loperamide

Indications: diarrhea

Adverse effects: drowsiness, urinary retention, dizziness

Contraindications: drug allergy, gastrointestinal blockage

Anti-diarrheal/opioid

Lactulose and Senna

Indications: constipation

Adverse effects: skin rashes, gastric irritation, electrolyte imbalance

Contraindication: drug allergy, fecal impacting

Laxative

Meclizine

Indications: nausea / vomiting associate with motion sickness, vertigo

Adverse effects: dizziness and drowsiness

Contraindications: drug allergy

Antihistamine

Metoclopramide (Reglan)

Indications: nausea and vomiting, delayed gastric emptying, and gastroesophageal reflux

Adverse effects: hypotension, sedation, restlessness

Contraindications: drug allergy

Prokinetics, seizure disorders, breast cancer, HI obstruction

Ondansteron (Zofran)

Indications: nausea and vomiting

Adverse effects: head, diarrhea, rash

Contraindications: drug allergy

Serotonin blocker

Ascorbic acid (vitamin c)

Indications: vitamin c deficiency, prevention and treatment of scurvy

Adverse effects: nausea, vomiting, headache, and abdominal cramps

Contraindications: drug allergy

Calcium

Indications: low calcium levels

Adverse effects: hypercalcemia, anorexia, constipation

Contraindications: hypercalcemia, dysrhythmias, drug allergy Serotonin

Vitamin k

Indications: dietary supplement and treats deficiency

Adverse effects: headache, rash, nausea, urticaria

Contraindications: drug allergy

epoetin alfa

Indications: anemia,

Contraindications: drug allergy, hypertension

(Must have adequate iron storage in body for drug to work)

Ferrous Sulfate

Indications: supplements and iron deficiency anemia

Adverse effects: nausea, vomiting, stomach cramps

Contraindications: drug allergy , hemolytic anemia

Folic Acid

Indications: folic acid deficiency

Adverse effects: allergic reaction, yellow discoloration in urine

Contraindications: drug allergy

Bacitracin

Indications: skin infections

Adverse effects: skin rash, anaphylactoid, itching, burning, and inflammation

Contraindications: drug allergy

Benzoyl Peroxide

Indications: acne

Adverse effects: related to dose, peeling of skin, redness, and sensation of warmth

Contraindications: drug allergy

Clotrimazole

Indications: fungal infections

Adverse effects: local irritation, pruritus, burning sensation, and scaling

Contraindication:

Pilocarpine

Indications: open angle

Glaucoma

Adverse effects: blurred vision

Contraindications: drug allergy

Timolol

Indications: elevated intraocular pressure

Adverse effects: blurred vision, pain, photophobia

Contraindications: drug allergy

Gentamicin

Indications: infection

Adverse effects: burning, stinging

Contraindications: drug allergy

Tetracaine

Indications: pain

Adverse effects: stinging, burning, redness, lacrimation

Contraindications: allergy

carbamide peroxide

Indications: ear wax

Adverse effects: none

Contraindications: drug allergy