Quiz 4 - Antibody Identification

The amount of antibody in the plasma is the—

a. dosage

b. avidity

c. titer

d. binding constants

c. titer

Which of the following are AHG phase antibodies?

a. Jka, K, Fya

b. D, M, A1

c. Lea, I, M

d. all of the above

a. Jka, K, Fya

Dosage effect in the blood bank refers to—

a. Stringer reaction with heterozygous cells

b. Negative reaction with heterozygous cells

c. Stronger reaction if the plasma to cell ratio is 2:1

d. Stronger reaction with homozygous cells

d. Stronger reaction with homozygous cells

Which of the following best describes the Kidd blood group antibodies?

a. React best at room temperature

b. Rapidly deteriorate in vivo

c. Do not bind complement

d. Are generally considered clinically insignificant

b. Rapidly deteriorate in vivo

Of the antibodies listed below, which set of antibodies generally reacts at room temperature?

a. Anti-D, -C, -E, -c, -e

b. Anti-Jka, -Jkb, -P1, -B

c. Anti-M, -Lea, -Leb, -P1

d. Anti-K, -k, -Kpa, -Kpb

c. Anti-M, -Lea, -Leb, -P1

When interpreting the results of an antibody panel, antigens can be crossed out—

a. on cells that give + reactions at any phase

b. on cells that give = reactions at any phase

c. on cells that give = reactions at all phases

c. on cells that give = reactions at all phases

True or false? HTLA antibodies may mask clinically significant alloantibodies

True

Antibody to a high prevalence antigen could be suspected when—

a. reacts in the same phase and strength with all panel cells

b. different phases of reactivity are observed with all panel and donor cells

c. reaction strength vary

d. none of the above

a. reacts in the same phase and strength with all panel cells

Four units are needed for a patient with anti-Fya and anti-K. How many units should you screen in order to find compatible units? Fya freq = 65%, K freq = 9%

a. 10

b. 8

c. 13

d. 20

c. 13

Multiple antibodies can be expected when—

a. the observed pattern of reactivity does not fit that of a single antibody

b. variations in reactivity strengths occur that cannot be explained based on antigen dosage

c. different phases of reactivity are observed

d. unexpected reactions occur when attempts are made to confirm the specificity of a single antibody

e. all of the above

e. all of the above

Antibody screening cells may not detect antibodies directed against low prevalence antigens. Which antigen is most likely to go undetected?

a. K

b. e

c. S

d. Kpa

d. Kpa

The ideal screening cells should include donor red cells with—

a. heterozygous expression of as many antigens as possible

b. homozygous expression of as many antigens as possible

c. heterozygous expression of the Duffy and Kidd blood group systems

d. homozygous expression of the Lutheran blood group system

b. homozygous expression of as many antigens as possible

In the primary antibody response to foreign antigen, the type of antibody initially formed is—

a. IgG

b. IgA

c. IgM

d. IgD

c. IgM

The term avidity refers to—

a. the removal of antibodies attached to antigen using magnetic resonance

b. the strength of anti-human globulin reaction

c. the pattern of agglutination displayed on HTLA antibodies

d. the strength with which an antibody binds to an antigen

d. the strength with which an antibody binds to an antigen

If an antibody panel displays variable strength reactions, which of the following should be considered?

a. multiple antibodies

b. dosage effect

c. an antibody directed toward an antigen that has variable strength among donors (e.g. P1)

d. all of the above

d. all of the above

Patients with multiple or rare antibodies may locate compatible units of blood—

a. from rare donor registries

b. from large blood suppliers

c. from directed donations

d. all of the above

d. all of the above

All of the following are examples of antibodies to high frequency antigens except—

a. anti-k

b. anti-Lua

c. anti-e

d. anti-I

b. anti-Lua

Duffy

Fya

Kell

k

Lutheran

Lub

MNSs

U

Kidd

Jka

Lewis

Leb

mixed field agglutination

transfused RBCs

positive DAT

in vivo RBC antigen antibody reaction

rouleaux

multiple myeloma

positive antibody detection

in vitro RBC antigen antibody reaction

antigen demonstrating dosage

M antigen

CAIHA

possible anti-I

WAIHA

antibody with possible Rh specificity