Pharm Ana part II Finals

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48 Terms

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Neutralization Reaction

Are Chemical processes in which an acid (protom donor) reacts with a base (proton acceptor).

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Water and Salt

These are the products of neutralization reaction in aqueous solution?

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Neutralization reaction

The reaction between acid and a base is called?

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Neutralization titration

Acid-base titration is also called as?

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Acidimetry

A specialized analytical technique used to determine the strength of an acid

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Alkalimetry

A special analytical technique we can use to determine the strength of a base or an alkaline compound

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Acidimetry

It is the reaction between a standard acid having known concentration and a base having an unknown concentration in the presence of a suitable indicator

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Alkalimetry

It is the reaction between a standard base or a alkaline compound having a known concentration and an acid having an unknown concentration in the presence of a suitable indicator

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Acidimetry

The tendency of an acid to dissociate forming protons and an anion

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Alkalimetry

The tendency of a base to accept protons from another chemical species

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Acidimetry

The determination of base by using a standard acid

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Alkalimetry

The determination of an acid using a standard base

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Amphoteric

Since water can behave as a weak base or a weak acid, what is the term used for it?

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Non-Aqueous titration

This procedure is very useful because it satisfies two different requirements namely - suitable titration of very weak and bases along with providing a with an ability to dissolve organic compounds.

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Bronsted-lowry theory and it's definition of acids and bases.

Many reactions which occur in non-Aqueous titration procedures can be explained via what theory?

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A base (to which a proton can be donate) is present

Potentially acidic substances can behave as acids only when?

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An Acid (from which a proton can be accepted) is present

Potentially basic substance can behave as bases only when?

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• It is impossible to tirate for a mix of acids or bases

• It is impossible to titrate for a mix of strong and weak acids (bases)

• It is impossible to titrate separately for a mix of acids (bases) with near constants of dissociation.

• It is impossible to define substance which are insoluble in water

Titration in water solution is limited by factors:

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Aprotic solvents

These solvents are:

• neutral in charge

• are chemically inert.

• generally have a low dielectric constant

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Protogenic solvents

These solvents are:

• more acidic in characters

• tend to have a leveling effect on the bases they come in contact with

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Protophilic solvents

These solvents:

• Have a basic character

• tend to react with the acids they come in contact with, leading to the formation of solvated protons

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Amphiprotic solvents

These solvents have the properties which are protophilic and protogenic.

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Crystal Violet

•considered the most common indicator in the titration of the bases.

• used as 0.5%w/v solution in glacial acetic acid

• color change from violet to blue to greenish yellow

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Quinaldine red

• employed as indicator in the determination of the drug substance in dimethylformide (DMF)

• It is used as 0.1%w/v solution in ethanol

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Thymol Blue

• used as 0.2%w/v solution in methanol.

• the color change is from yellow to blue.

• used as an indicator for the titration of substances acting as acids in DMF.

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Suitable pH indicator

Must be chosen to detect the endpoint of the titration. The color changes or other effect should occur close to the equivalence point of the reaction.

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Neutral (pH=7)

A strong acid will react with a strong base to form a?

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Acidic (pH<7) solution

A strong acid will react with a weak base to form a?

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Basic (pH>7) solution

A weak acid will react with a strong base to form a?

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(1) To determine the endpoint in neutralization process

(2) To determine hydrogen-ion concentration or pH

(3) To indicate that a desired change in pH has been affected

Indicators are complex organic compounds used:

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Litmus - Blue

Phenolphthalein - Pink

Methyl orange - yellow

Screened methyl orange - orange

Bromothymol blue - Blue

Wood ash, soap solution, ammonia solution, sodium hydroxide

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Litmus - red

Phenolphthalein -colorless

Methyl orange - red

Screened methyl orange - purple

Bromothymol blue - orange

Hydrochloric acid, Sulphuric(VI)acid and lemon juice

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Litmus - colorless

Phenolphthalein - colorless

Methyl orange - red

Screened methyl orange - orange

Bromothymol blue - orange

Distilled water and sodium chloride

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Litmus - blue

Phenolphthalein - Pink

Methyl orange - yellow

Screened methyl orange - orange

Bromothymol blue - Blue

Sour milk, toothpaste and calcium hydroxide

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Acid - Yellow

Base - blue

Bromocresol green, bromophenol blue and bromothymol blue

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Acid - yellow

Base - purple

Bromocresol purple

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Acid - yellow

Base - Red

Cresol red

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Acid - yellow

Base - Violet

Cresol red-Thymol blue TS

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Acid - Yellow

Base - Green

Malachite green

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Acid - Red

Base - Yellow

Methyl red and Methyl Yellow

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Acid - Red-Violet

Base - Green

Methyl red-Methylene Blue TS

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Acid - colorless

Base - Red

Phenolphthalein and Quinaldine red

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Acid - Yellow

Base - Red

Phenol Red

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Acid - Yellow

Base - Blue

Thymol blue

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Acid - Colorless

Base - Blue

Thymolphthalein

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  1. Dichlorofloresein TS

  2. Eosin Y

  3. Ferric ammonium Sulfate TS

  4. Potassium Chromate TS

  5. Sodium Alizarin TS

  6. Tetrabromophenolphthalein TS

  7. Tetrabromophenolphthalein, Ethyl Ester TS

Indicator employed in precipitation

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  1. Azo-Violet

  2. Crystal violet TS

  3. Malachite green

  4. Methyl red

  5. Methyl violet

  6. p-Naphtholbenzein

  7. Phenol red

  8. Quinaldine Red

  9. Thymol blue

Indicators for Non-Aqueous titration

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  1. Diphenylamine

  2. Dithizone(Diphenylthiocarbazone)

  3. Eriochrome black

  4. Methyl red

  5. Hydroxynaphthol blue

  6. Murexide

  7. Naphthol green

  8. 1-(2-Pyridylazo)-2-napthol

Indicators for complexometric Titration