lymph node development and T cell migration

What chemokine is produced by lymph node stromal cells, starting the process of cellular recruitment into the lymph node?

CCL21

Where do we find the follicular dendric cells?

follicle

Diapedesis is the process of the T cell moving between the endothelial cells. This process is mediated by

chemokine gradient

Naive T cells enter lymph nodes via endothelial cells call HEVs. The first stage of entry is "rolling" along the HEVs. What on the surface of the T cell stimulates the "rolling?"

selectins

What chemical in the blood attracts T cells out of the lymph node?

S1P

What chemokine receptor is expressed on activated dendritic cells that causes them to migrate to the lymph node?

CCR7

When do dendritic cells (DC) express the most B7 on the surface of their cells?

Activated DCs in the lymph node

When do dendritic cells (DC) express the most phagocytic receptors like dectin-1 and DC-SIGN?

resting DCs in the tissue

Lymphnodes organize around gradients of...

chemokines

This cell is the fist to enter a lymph node.  It produces CCL21, creating the gradient that stimulates the chemotaxis of the other cells that make up the mature lymph node.

stromal cells

Immature dendritic cells are attracted to tissue because they express tissue specific chemokine receptors like…

CCR 1,2,5, or 6

Activated dendritic cells are attracted to lymph nodes because they express the lymph node specific chemokine receptor…

CCR7

Naïve T cells, expressing CD28, engage with activated Dendritic cells via the TCR/MHC and CD28

B7