L3 Proteins in defense of oral health

different ways saliva helps maintain oral health

antimicro defense, mineral homeostasis, digestion, ph regulation, lubrication + protection

what protein for each of the following: antimicro defense (2), mineral homeostasis, digestion, ph regulation, lubrication + protection

histatins + secrecory iga, statherin, SA, buffer sys, mucins

how do histatins provide antimicrobial defense? Which microbe and what kind of infections does it defend against?

provides potent fungicide by binding, entering, and disrupting the production of the yeast C albicans

Enamel is made up of__crystals that are made of__and__. Saliva contains__ which is a salivary __ that helps maintain tooth structure through__ . If the tooth is demineralized, this can help __it and protect tooth enamel.

Hydroxyapatite, calcium, phosphate, statherin,Phosphoprotein, mineral homeostasis, remineralize

SA is a__which initiates __in the oral cavity. It requires__for catalytic activity to create an__ and perform this action.

globular, enzyme, starch, digestion, protein folding, active site

Secretory, IGA is an example of a protein that defends not by killing, but rather,__which prevents__. As a reminder, one of the important interactions in it is__

recognizing and binding; attachment; disulfide bonds

Match each of the 4 functions to the different proteins: mineral surface binding, substrate binding, microbial interaction, antigen recognition

statherin, SA, histatin, secretory IGA

Protein function being carried out correctly depends on correct__and__ to the correct __

folding, binding, targets

What do histatins recognize/bind to and what is the function of this?

microbial targets/yeast; antimicrobial defense

What do statherins recognize/bind to and what is the function of this?

hydroxyapatite/mineral services; mineral homeostasis

What do SA recognize/bind to and what is the function of this?

starch: digestion

What do secretory IGA recognize/bind to and what is the function of this?

microbial antigens; prevention of microbial attach

Mucins are heavily__salivary proteins. This type of modification of added carbohydrate chains occurs__. Glycosylation increases ___ and glycosylated mucins helps with ___ by ___.

glycosylated, post-translation, stability, protection, lubricating

Post translational modifications can change protein__

function