exam 1 practice questions

what cell is this characteristic of? endogenous pathway of antigen presentation with MHC I

CD8 T cells

adaptive immunologic reliance to most intracellular pathogens is mediated by what?

cell-mediated immunity

how many antigen binding sites are on the f(ab)’2 fragment of an antibody

2

what type of biological molecule can be recognized as antigenic by both B and T cells

proteins

T cell growth factor is the function of which cytokine

IL-2

inhibition of viral replication is the function of what cytokine

IFN-A/B

recruiting neutrophils to the site of an infection is the function of what cytokine

IL-8

activation of macrophages is characteristic of what cytokine

IFN-gamma

promotion of th1 differentiation is characteristic of what cytokine

IL-12

antibody dependent cellular cytotoxicity and destruction of target cells lacking MHC I expression is characteristic of what cell

Natural killerht

the function of cd4+ th2 T cells is to promote

humoral immunity

this cytokine is secreted by cd4+ T cells and is an example of the adaptive response amplifying innate by increasing differentiation of neutrophil precursors into neutrophils and the adhesion of neutrophils to vascular endothelial cells

IL-17

mitogens activate lymphocytes by binding to what

surface molecules on a B cell other than BCR

production and expression of which molecule by APCs helps the APC to activate naive helper T

B7

if a patient lacked CD40 on B cells, what would they most likely lack

IgG

these stimulate the release of acute phase cytokines by cross linking the TCR and MHC II molecules

superantigens

these are caused by IgE mediated mast cell degranulation

wheal and flares

chronic delayed type hypersensitivity reactions are mediated by what

activation of macrophages by IFN-gamma

natural antibodies that bind to ABO blood group antigens and are found in normal serum re

cross reactive with bacteria

receptor for the Fc portion of IgE are expressed on

mast cells and basophils

proteins which can activate T cell, which provide help signals to B cells that promote isotope switching

t-dependent antigens

this occurs in the thymus and involves TCR rearrangement, positive and negative selection

antigen-independent T cell development

carbohydrates- induce only IgM antibody response

t-independent antigens

this occurs in secondary lymphoid organs and T cells becomes activated by foreign protein antigen presented in their MHC

antigen-dependent T cell activation