M6 - QA & QC

B) Mycoplasma

Which of the following lacks a cell wall?
A. Clostridium
B. Mycoplasma
C. Mycobacterium
D. Nocardia

D) Hemolysin

Which of the following are enzymes that damage the red blood cell?
A. Lecithinase
B. Endotoxins
C. Protease
D. Hemolysin

A) Bacillus subtilis

Which of the following do you expect to be the MOST resistant to high temperatures?
A. Bacillus subtilis
B. Neisseria gonorrhoeae
C. Escherichia coli
D. Staphylococcus aureus

C) Secondary malnutrition

A type of malnutrition associated with inadequate mastication, digestion, absorption, transport and excretion of nutrients.
A. Primary malnutrition
B. Under nutrition
C. Secondary malnutrition
D. Over-nutrition

B) I, II, and IV

Which of the following are identified world wide as "ESKAPE" pathogens?
I. Enterococcus faecalis
II. Acinetobacter baumannii
III. Candida albicans
IV. Pseudomonas aeruginosa
A. I, II, III, IV
B. I, II, and IV
C. II, III and IV
D. I, II, and III

C) Variola virus

Which of the following is the pathogen for smallpox?
A. Plasmodium
B. Aedes aegypti
C. Variola virus
D. Rubella virus

A) Streptococcus agalactiae

Group B staphylococcus that causes neonatal meningitis and sepsis?
A. Streptococcus agalactiae
B. Streptococcus pyogenes
C. Staphylococcus aureus
D. Staphylococcus epidermidis

B) Tse-tse flies

What is the vector of a disease known as African Trypanosomiasis?
A. Mosquitoes
B. Tse-tse flies
C. Lice
D. Dust mites

D) Clostridium botulinum

Causative agent of food poisoning from canned goods.
A. Corynebacterium diphtheriae
B. Clostridium perfringens
C. Gonococcus
D. Clostridium botulinum

A) D-glutamic acid

The capsule of Bacillus anthracis is composed of?
A. D-glutamic acid
B. Polysaccharide
C. L-glutamic acid
D. Nucleic acid

D) Travelling to endemic areas

Patients with malaria should be asked about which of the following?
A. Airdroplet transmission
B. Sexual contact
C. Eating of exotic foods
D. Travelling to endemic areas

C) Mesophiles

Which among the following is the organism that can grow at body temperature?
A. Psychrophiles
B. Thermophiles
C. Mesophiles
D. Acidophiles

A) Corynebacterium diphtheriae

In stained smear what looks like a Chinese letter arrangement having metachromatic granules? Infects the respiratory system.
A. Corynebacterium diphtheriae
B. Gonococcus
C. Clostridium botulinum
D. Clostridium perfringens

D) Dengue

Promoting the "four o'clock habit", is all about the DOH program for prevention and control of which of the following disease?
A. Malaria
B. Malnutrition
C. Tuberculosis
D. Dengue

C) Mortality rate

Which of the following indices represents the index that measures the number of individuals who have died within a susceptible population during a specific period because of a particular disease?
A. Prevalence rate
B. Virulence
C. Mortality rate
D. Morbidity rate

D) Morbidity rate

Which of the following indices refers to the measure of the number of individuals who become ill because of a specific disease within a susceptible population during a specific period?
A. Morbidity ratio
B. Prevalence rate
C. Mortality rate
D. Morbidity rate

A) Trypanosomiasis

Which of the following is NOT a primary sexually transmitted disease (STD)?
A. Trypanosomiasis
B. Genital herpes
C. Gonorrhea
D. Lymphogranuloma venereum

A) Immunization

Primary Health Care pertains to ____?
A. Immunization
B. MRI/CT scan
C. Cardiovascular stress test
D. Bone densitometry

C) Staining method

The following may be useful when performing microbiological assay of antibiotics, EXCEPT?
A. Test tube inoculation
B. Paper disc
C. Staining method
D. Cylinder plate

C) Copper

A trace mineral necessary for heme synthesis, electron transport and wound healing
A. Manganese
B. Chromium
C. Copper
D. Zinc

A) Flagella

The bacterial organelle that is used for motility:
A. Flagella
B. Pili
C. CIllia
D. Pseudopods

A) Mumps

The following are zoonotic disease, except:
A. Mumps
B. Anthrax
C. Leptospirosis
D. Brucellosis

C) Dipicolinic acid

The substance responsible for the heat resistance of endospores:
A. Polymerized D-glutamic acid
B. Flagellin
C. Dipicolinic acid
D. Teichoic acid

D) Dark-field microscopy of lesion scrapings if a chancre is present

The diagnosis of early syphilis is best made by:
A. Inoculating guinea pigs with lesion material and examining blood smears 3 days later
B. Culture on chocolate agar and incubated with 10% carbon dioxide
C. The VDRL test
D. Dark-field microscopy of lesion scrapings if a chancre is present

B) Fomite

An object that is able to harbor and transmit microorganisms:
A. Mite
B. Fomite
C. Arthropod
D. Vector

C) Bacillus stearothermophilus

A biological sterilization indicator used to test autoclave efficiency:
A. Virus
B. Bacillus thuringiensis
C. Bacillus stearothermophilus
D. Clostridium botulinum

B) Mycoplasma species

The smallest known free-living microorganism is:
A. Viruses
B. Mycoplasma species
C. Rickettsia
D. Chlamydia

B) Staphylococcus aureus

In microbial assay of antibiotics, what organism is used for penicillin G?
A. Escherichia coli
B. Staphylococcus aureus
C. Bacillus subtilis
D. Pseudomonas aeruginosa

C) Mitochondria

Which one is not found in prokaryotic cell?
A. Cell membrane
B. Plasmids
C. Mitochondria
D. Chromosomes

D) transduction

Which of the following is a process of gene transfer where the carrier of DNA is a virus?
A. Sporulation
B. conjugation
C. transformation
D. transduction

D) Sporulation

Which of the following is the formation of dormant form of bacteria when conditions are inhospitable?
A. Mutation
B. Polymorphism
C. Germination
D. Sporulation

C) There was absence of air.

Regarding Pasteur's experiment with the S-neck flask, all of the following statements are true, EXCEPT _____.
A. All microorganisms were killed before beginning.
B. There was food source involved.
C. There was absence of air.
D. Any possibility of contamination was removed.

D) Treponema

Which of the following is not gram-positive?
A. Corynebacterium
B. Bacillus
C. Staphylococcus
D. Treponema

B) Mycobacterium leprae

Which of the following is the identified cause of Hansen's disease?
A. Mycoplasma leprae
B. Mycobacterium leprae
C. Mycobacterium bovis
D. Mycobacterium tuberculosis

D) Paramecium

Which of the following is NOT a fungus?
A. Yeast
B. Penicillium
C. Molds
D. Paramecium

A) Direct or indirect contact with infected birds

How is avian flu or bird flu transmitted?
A. Direct or indirect contact with infected birds
B. Inhalation of contaminated aerosols
C. Animal bites
D. Mosquito bites

B) Candida albicans

Which of the following is caused by an opportunistic pathogen for compromised systems?
A. Trichomonas vaginalis
B. Candida albicans
C. Neisseria gonorrheae
D. Herpes Simplex Virus

D) Ethylene oxide

Which of the following substances can sterilize?
A. Alcohols
B. Chlorine
C. Soap
D. Ethylene oxide

B) Animalia

Which of the following is NOT domain in the three-domain system?
A. Archaea
B. Animalia
C. Bacteria
D. Eukarya

A) Salmonella

Causative agent of typhoid fever is______.
A. Salmonella
B. Aspergillus
C. Shigella
D. Rickettsia typhi

A) Gram negative

In gram staining, a bacterial cell that will stain pink to red, the specimen will be labeled as___.
A. Gram negative
B. Pink is not an observed color in gram stain
C. Gram positive
D. Gram variable

A) Leptospira interrogans

Which among the list is the spirochete causing leptospirosis?
A. Leptospira interrogans
B. Borell burgdorferi
C. Treponema pallidum
D. Mycobacterium leprae

C) Tinea pedis

Which causes athlete's foot?
A. Tinea capitis
B. Tinea corporis
C. Tinea pedis
D. Tinea cruris

A) Requires X and V factors

Which of the following is NOT a characteristic/s of Neisseria?
A. Requires X and V factors
B. Oxidase-positive
C. Cocci
D. Gram-negative

A) Physical

Which type of industrial hazard includes ambient heat, burn, noise and vibration?
A. Physical
B. Chemical
C. Global
D. Biological

D) Beri-beri

Which is due to thiamine deficiency?
A. Cystitis
B. Pellagra
C. Stomatitis
D. Beri-beri

C) Colostrum

Which component of milk has antibodies?
A. Lactose
B. Cream of milk
C. Colostrum
D. Fructose

D) Zinc

Which of the following elements is associated to improve immune system?
A. Sodium
B. Chlorine
C. Iodine
D. Zinc

B) Humans

Choose the reservoir for chicken pox infection.
A. Pigs
B. Humans
C. Chicken
D. Cattles

B) Handshake

Which of the following is common route of transmission for COVID-19, SARS and common cold?
A. Needlestick injury
B. Handshake
C. Animal bites
D. Contact with contaminated urine

C) 90-110%

What is the typical range of acceptance criteria for assay results as found in the labeled claim?
A. 75-100%
B. 85-95%
C. 90-110%
D. 100-110%

D) Diazotization titration

Which of the following is used in the analysis of aromatic compounds containing an amino group in the molecule?
A. Acid-base titration
B. Proximate assay
C. Acetylation process
D. Diazotization titration

A) Lambert or Bouger's Law

Which of the following laws in Spectrometry express the mathematical relationship between light transmittance and thickness of the solution?
A. Lambert or Bouger's Law
B. Charles' Law
C. Beer's Law
D. Henry's Law

A) Volumetric flask

What is used for quantitative preparation of a standard solution?
A. Volumetric flask
B. Pipet
C. Buret
D. Graduated Cylinder

C) First expiry first out

To control finished products in the warehouse of a company. What is the distribution practice?
A. First in- First out
B. First in last out
C. First expiry first out
D. Last in first out

C) Staining method

The following may be useful when performing microbiological essay of antibiotics, EXCEPT?
A. Test tube inoculation
B. Paper disc
C. Staining method
D. Cylinder plate

A) Carbon monoxide

Air contaminant causing death by asphyxiation in high concentration
A. Carbon monoxide
B. Lead
C. Oxygen
D. Carbon dioxide

B) Suspensions

Which of the pharmaceutical formulations will special methods like turbidimetric and nephelometric assays are applicable?
A. Elixirs
B. Suspensions
C. Solutions
D. Waters

D) Stability

Which of the following term refers to the characteristics of the drug product to retain its chemical, physical, therapeutic and toxicologic specification while inside its container?
A. Shelf-life
B. Quality
C. Expiry date
D. Stability

D) 90%

The period of the stability of a preparation is the time from the date of manufacture of the formulation until its biological or chemical activity is no less than how many percent of the labeled potency?
A. 85%
B. 95%
C. 93%
D. 90%

A) Potency

The United States Pharmacopeia (USP) content uniformity test is used to ensure which quality?
A. Potency
B. Bioequivalency
C. Purity
D. Toxicity

B) Gasometric

Techniques used in the test for the presence of bacterial endotoxins (BET) include the following, EXCEPT ____.
A. Chromogenic technique
B. Gasometric
C. Gel-clot technique
D. Turbidimetric technique

C) pH determination

In what analytical process would Potentiometric A. Acid value determination method be MOST applicable?
A. Acid value determination
B. Biological assay
C. pH determination
D. moisture determination

B) Lost sufficient activity to be outside USP/NP monograph requirement

Which among the statements defines the status of drug beyond expiration date?
A. Lost 50% of drug activity
B. Lost sufficient activity to be outside USP/NP monograph requirement
C. Activity is below label claim
D. Has lost 90% of activity

A) DOP test

What is used in assessing efficiency of HEPA filter?
A. DOP test
B. Rodac plate test
C. Bubble point test
D. Powdered glass test

B) HPLC

Widely used and preferred current assays of biological and pharmaceutical product is ____.
A. TLC
B. HPLC
C. Gravimetric method
D. GC

A) Milliliter

the following are units of measurements generally used inn spectrometry, EXCEPT____
A. Milliliter
B. Nanometer
C. Micrometer
D. Angstrom

C) Precision

In methods of analysis, which of the following refers to an expression of closeness of agreement between a series of measurements?
A. Robustness
B. Accuracy
C. Precision
D. Specificity

B) Capping

It is the partial or complete separation of the top or bottom of a tablet from the main body
A. Lamination
B. Capping
C. Mottling
D. Picking

A) 50 mg or smaller

Content uniformity test is to be performed for all tablet products whose active ingredient is:
A. 50 mg or smaller
B. 130-324 mg
C. 324 mg or more
D. 130 mg or less

B) Friabilator

An instrument used to measure the durability of tablets to shipping/transportation against shock and abrasion.
A. Metal detector
B. Friabilator
C. Top loading balance
D. Colorimeter

D) 85-115%

USP limit for tablet content uniformity:
A. 90-110%
B. 95-110%
C. 90-100%
D. 85-115%

D) Both A and B

The test used to determine the strength of tablets includes:
A. Content uniformity
B. Hardness
C. Weight variation
D. Both A and B

B) 5.5 cm

Determine the distance traveled by the solute, if its Rf value is 0.688 and the solvent travels 8.0 cm. the sample weight is 1.02 mg.
A. 11.6 cm
B. 5.5 cm
C. 11.8 cm
D. 0.70 cm

A) 0.5N H2SO4

If the gram molecular weight of sulfuric acid is 98. Which of the following will be used to label the container of a solution containing 49 grams per liter of solution?
A. 0.5N H2SO4
B. 1N H2SO4
C. 1M H2SO4
D. 0.2M H2SO4

B) packaging materials

Caps, bottles, labels, and shipping containers are classified as what?
A. accessories
B. packaging materials
C. drug products
D. active components

C) Contents are protected from extraneous solids, liquids and vapors

When packaging and storage requirements specify a "hermetic container" it is understood that the
A. Contents are protected from extraneous solids
B. Contents are protected from extraneous solids and liquids
C. Contents are protected from extraneous solids, liquids and vapors
D. Contents are protected from extraneous solids, liquids, vapors and gas

A) Weight variation

The quality of pharmaceutical products is compromised by adulteration which may be brought about by the following EXCEPT?
A. Weight variation
B. Addition of another article
C. Spoilage due to microorganisms
D. Substitution of ingredients

C) Ash Content Determination

The following are established product quality tests for injection solution EXCEPT _________?
A. Particulate Matter Content Determination
B. Sterility Test
C. Ash Content Determination
D. pH Determination

A) 20.15

Compute for the gram equivalent weight of MgO (mw=40.30)]
A. 20.15
B. 0.0403
C. 0.403
D. 0.2015

B) Proximate

Which of the following assays will involve total alkaloidal determination?
A. Specific
B. Proximate
C. Extraction
D. Ultimate

B) Inventory control

Which of the following processes is NOT considered as a quality control (QC) function?
A. Inspection of containers
B. Inventory control
C. In-process analysis
D. Labeling ang packing materials

D) 45 mL

How much of the alkali solution will be required to neutralize 30 ml of the acid if 1 ml of HCl is equivalent to 1.5 ml of 0.5N NaOH?
A. 50 mL
B. 40 mL
C. 35 mL
D. 45 mL

A) Strict adherence to standards combines with quality

Which of the following statements will correctly define the total quality of a pharmaceutical product?
A. Strict adherence to standards combines with quality
B. Use of state-of-the-art equipment and advance technology means total quality.
C. Quality is everybody's business in a pharmaceutical establishment.
D. Production department is responsible for quality.

C) Saponification value

Koettsdorfer number is the common name for which of the following values?
A. Ester value
B. iodine value
C. Saponification value
D. acid value

C) Fluorimetry

What special instrumental method is used in the assay of thiamine?
A. Colorimetry
B. Refractometry
C. Fluorimetry
D. Potentiometry

D) treatment with a solution of sodium chromate in sulfuric acid

What would be the most effective manner of cleaning glass apparatus?
A. rinsing with nitric acid
B. soaking in acetic
C. soaking in detergent
D. treatment with a solution of sodium chromate in sulfuric acid

C) Gravimetric method

Which of the following terms is used for the method of analysis done by separation of the constituent from the sample and then consequently weighing the product?
A. Special method
B. Volumetric method
C. Gravimetric method
D. Gasometric method

B) Arrhenius equation

Which equation is used to predict the shelf life of a drug product?
A. Michaelis Menten equation
B. Arrhenius equation
C. Hixson Crowell equation
D. Stokes equation

C) Cheap price

Pharmaceutical products of good quality and acceptability should possess or exhibit following characteristics, EXCEPT ____
A. Therapeutically effective
B. Free of adulterants
C. Cheap price
D. Safe

B) About getting things right all along the line

Good manufacturing practice (GMP) as part of quality assurance simply means _____
A. Personnel must be properly trained
B. About getting things right all along the line
C. Environmental cleanliness and hygiene must be observed
D. All records and documentation must be in place

A) Silica gel

What constitutes the stationary phase used in thin layer chromatography (TLC)?
A. Silica gel
B. Aqueous salt solution
C. Alumina
D. Cellulose

B) Oxidation- reduction

What chemical reaction is involved during analysis wherein there occur a change of valence of reacting substances?
A. Neutralization
B. Oxidation- reduction
C. Complexation
D. Precipitation

D) Karl Fischer Method

Water content determination Method 2
A. Gravimetry
B. Titrimetry
C. Azeotropic Method
D. Karl Fischer Method

A) masking agents

These are chemicals used to prevent one element from interfering in the analysis of another element
A. masking agents
B. demasking agents
C. auxiliary complexing agent
D. indicator

D) 92%

If the sample of beeswax has an acid value of 18.45 and ester value of 74, what is the saponification number of the sample?
A. 85%
B. 88%
C. 98%
D. 92%

D) 3

To find the gram equivalent weight of Phosphoric acid, divide its molecular weight by:
A. 1
B. 0
C. 2
D. 3

C) Alkalimetry

The direct or residual titrimetric determination of organic or inorganic acids using an accurately measured volume of base:
A. Acidimetry
B. Precipitimetry
C. Alkalimetry
D. Oxidimetry

A) Blank solution

Solutions containing all the reagents and solvents used in the analysis, but no deliberately added analyte.
A. Blank solution
B. Solution with sample
C. Standard solution
D. Test solution

A) Kjeldahl analysis

The most widely employed acid–base titration is for organic nitrogen
A. Kjeldahl analysis
B. Titrimetric analysis
C. Potentiometric analysis
D. Chromatographic analysis