Clinical Chemistry 2- Quiz 28 Tumor Markers

Board Review Question: Measurement of the serum acid phosphatase is used to detect neoplastic disease of the

prostate

Board Review Question: Serum from a patient with metastatic carcinoma of the prostate was separated from the clot and stored at room temperature. The following results were obtained:

acid phosphatase with freshly drawn serum

Board Review Question: In developing the reference range for a new EIA for CEA, the range for the normal population was broader than that published by the vendor. Controls are acceptable with a narrow CV. This may be explained by

inclusion of smokers and non-smokers in the study population

Which of the following biomarkers is elevated in nonmucinous epithelial ovarian cancer?

CA 125

Which of these biomarkers can be used to monitor colorectal cancer?

CEA

Alkaline phosphatase can be used as a tumor marker for

All of these are correct.

Which of the following indications is most useful for protein-based tumor markers?

Monitoring for therapeutic efficacy

Which of the following is FALSE about PSA?

It is not elevated in benign prostatic hyperplasia

Which of these biomarkers is used to monitor pancreatic cancer?

CA 19-9

Which of the following biomarkers are elevated in advanced stages of breast cancer?

CA 15-3 and CA 549

What oncofetal antigen is associated with liver cancer?

AFP

In which of the following conditions is the prostate-specific antigen most likely to fall within the reference range?

Post-radical prostatectomy

Elevated carcinoembryonic antigen levels are commonly associated with what type of cancer?

Colorectal cancer

What is the primary purpose of clinical assays for tumor markers?

Monitoring the course of a known cancer

What is the clinical significance of an elevated hCG result in a male patient?

Testicular cancer

Which of the following tumor markers is useful for following patients with ovarian cancer?

CA 125

Elevation in serum calcitonin is associated with what type of cancer?

Thyroid

Which of the following genetic markers is used to screen for susceptibility to breast cancer?

BRCA-1/BRCA-2

A 60-year-old man has a PSA level of 4.5 ng/mL. What is the most appropriate course of action?

Order a free PSA test

An elevated CSF concentration of neuron-specific enolase assists in the diagnosis of which of the following?

Creutzfeldt-Jakob disease

Board Review Question: Estrogen and progesterone receptor assay are useful in assessing prognosis in which of the following?

breast cancer

Which molecular form(s) is/are measured by an intact B-hCG assay?

The whole molecule

Which test doubles as a marker for pregnancy and gonadal tumor?

Human choriogonadotropin

A markedly elevated serum AFP is associated with which of the following?

Hepatocellular carcinoma

Tumor marker test are the most beneficial for:

monitoring therapy

Board Review Question: A serum sample for acid phosphatase determination is best prepared for room temperature storage by

adding an acid stabilizer

Which of the following assays is recommended as a screening test for colorectal cancer in persons over 50 years of age?

Occult blood test

Which is true concerning the difference between malignant and benign tumors?

Benign tumors are well-differentiated cells.

What is the primary clinical usefulness of measuring carcinoembryonic antigen?

Monitoring for recurrence of colon cancer

Which of the following is a sialylated Lewis blood group antigen associated with colorectal cancer?

CA 19-9

The definition of an oncofetal antigen is

proteins expressed during the fetal period that are not expressed in normal adults but are produced by cancerous cells.

The production of alpha fetal protein (AFP) in a healthy individual is best reflected by which of the following statements?

The production of AFP declines rapidly at birth and healthy adults and children have negligible or undetectable levels in serum

In which of the following disorders would the maternal serum level of alpha1-fetoprotein be elevated?

Neural tube defect.

Which of these methods is the primary method for tumor marker assays?

immunoassays

Board Review Question: Clinical assays for tumor markers are most important for

monitoring the course of a known cancer