Corso - acetylcholine

what receptors does acetylcholine activate?

nicotinic receptors (N1 and N2)

muscarinic receptors (m1-5)

acetylcholine is a ________

biogenic amine

list the names of the biogenic amine neurotransmitters

acetylcholine

dopamine

norepinephrine

epinephrine

5-HT

melatonin

histamine

what NT is this?

acetylcholine

what enzyme is used for the single step of acetylcholine synthesis?

choline acetyltransferase

what enzyme is used to degrade acetylcholine?

acetylcholinesterase

what acetylcholine receptor classes are FAST?

a. N1 and N2

b. m1, m3, m5

c. m2 and m4

a.

what acetylcholine receptor classes are SLOWER?

a. N1 and N2

b. m1, m3, m5

c. m2 and m4

b. c.

what acetylcholine receptor classes are excitatory - ligand gated sodium channels?

a. N1 and N2

b. m1, m3, m5

c. m2 and m4

a.

what acetylcholine receptor classes are excitatory via G-alpha-q, increasing IP3 and DAG?

a. N1 and N2

b. m1, m3, m5

c. m2 and m4

b.

what acetylcholine receptor classes are inhibitory via G-alpha-i, decreasing cAMP?

a. N1 and N2

b. m1, m3, m5

c. m2 and m4

c.

where is major ACh input?

hippocampus

ACh depletion in hippocampus causes ______

Alzheimer’s —> short term memory loss

which is the excitatory G-protein?

a. G-alpha-s

b. G-alpha-i

a.

which is the inhibitory G protein?

a. G-alpha-s

b. G-alpha-i

b.

which G protein results in increased cAMP?

a. G-alpha-s

b. G-alpha-i

a.

which G protein results in decreased cAMP?

a. G-alpha-s

b. G-alpha-i

b.

how do you obtain choline?

diet

acetyl coA is produced by _______

metabolism

choline acetyl transferase synthesizes ACh in the __________

cytoplasm

_____ is an immune disorder against the voltage gated calcium channels

LEMS

describe LEMS

disorder against voltage gated calcium channels

decreases the amount of ACh released at neuromuscular junction

__________ is an autoimmune disorder that blocks neuromuscular signaling

myasthenia gravis

what is TYPICAL myasthenia gravis (MG)?

autoantibodies to the alpha1 subunit of the N1 acetylcholine receptor

what is acquired slow channel syndrome?

autoantibodies to the epsilon subunit of the N1 acetylcholine receptor

what is neonatal myasthenia gravis (transient) or recurrent arthrogryposis

autoantibodies to the gamma subunit of the N1 acetylcholine receptor

what is the most common treatment for LEMS and MG?

acetylcholinesterase inhibitors

what does botox do?

inhibits ACh release

what does atropine do?

m receptor antagonist

what does nicotine do?

N receptor agonist

what does muscarine do?

M receptor agoonist

a patient is suffering from myasthenia gravis, which class of drugs is most commonly prescribed?

a. acetylcholinesterase inhibitors

b. amphetamines

c. antibiotics

d. MAOIs

e. N1 receptor antagonists

a.

atropine is a:

a. N receptor agonist

b. M receptor agonist

c. N receptor antagonist

d. M receptor antagonist

d.

which of the following areas receives the heaviest projections from the nucleus basalis?

a. cerebellum

b. hippocampus

c. pons

d. substantia nigra

b.