Transfusion Reactions

Flashcards covering the types, mechanisms, timing, and manifestations of blood transfusion reactions.

Acute hemolytic transfusion Rxn

A reaction occurring during or immediately after transfusion caused by host antibody against donor RBCs and ABO incompatibility, resulting in inflammation, fever, back/flank pain, hemolysis, and hemodynamic instability.

Febrile non hemolytic transfusion Rxn

A reaction occurring within 1-6 hours caused by host antibodies against donor WBCs and the release of cytokines from donor WBCs, characterized by fever without hemolysis.

Anaphylatic transfusion reaction

An immediate Type I hypersensitivity reaction caused by an allergy to proteins in donor blood or an allergy to IgA in patients with IgA deficiency.

Transfusion related acute lung injury

A reaction caused by donor antibodies against host neutrophils and donor antibodies against pulmonary endothelial cells, leading to pulmonary edema / distress.