Lecture on NMDA Receptor Antagonists and Dissociatives

A collection of vocabulary flashcards based on the concepts, definitions, and critical information related to NMDA receptor antagonists and their mechanisms.

NMDA Receptor

A type of glutamate receptor that is the target for certain anesthetics, including ketamine and PCP.

Ketamine

A dissociative anesthetic that is used both medically and recreationally, often associated with feelings of detachment and a 'K hole' at high doses.

PCP (Phencyclidine)

An anesthetic agent that produces dissociative effects but was removed from clinical use due to undesirable psychological effects.

Salvinorin A

The active compound in Salvia divinorum, a Kappa opioid receptor agonist that induces hallucinogenic effects.

Dextromethorphan (DM)

An over-the-counter cough suppressant that acts as a dissociative anesthetic at high doses.

Dissociative Anesthetic

A class of drugs that induce a trance-like state and a sense of detachment from the body or environment.

Glutamate

The major excitatory neurotransmitter in the brain, playing a key role in synaptic transmission and plasticity.

Kappa Opioid Receptor (KOR)

A type of opioid receptor that, when activated by compounds like Salvinorin A, can produce hallucinogenic effects.

Chronic Ketamine Use

Associated with negative effects such as urinary pain, cognitive impairments, and potential bladder syndrome.

Reward Mechanism

The processes by which drugs activate the brain's reward pathways, leading to the reinforcement of drug use behavior.

PCP Abuse

Refers to the recreational use of PCP, often resulting in agitation and hallucinations, commonly known as 'angel dust'.