USMLE Step 3 High-Yield Mistakes: Nephrology, Rheumatology, and Vasculitis

A collection of fill-in-the-blank practice questions based on high-yield USMLE Step 3 notes covering nephrotic syndromes, autoantibodies, vasculitis, kidney stones, and hyponatremia.

In a child, the most common cause of nephrotic syndrome is __________ .

Minimal Change Disease

Nephrotic syndrome associated with HIV, obesity, heroin use, or sickle cell disease is __________ .

FSGS

Nephrotic syndrome associated with HBV, HCV, or solid tumors is __________ .

Membranous Nephropathy

The cause of nephrotic syndrome commonly associated with DM is __________ .

Diabetic Nephropathy

Multiple Myeloma is associated with the nephrotic syndrome __________ .

Amyloidosis

The autoantibodies Anti-dsDNA and Anti-Smith are specific for __________ .

SLE

Anti-centromere antibodies are characteristic of __________ .

CREST

Anti-Scl-70 is the autoantibody found in __________ .

Diffuse Scleroderma

Anti-Jo-1 is the marker for __________ .

Antisynthetase Syndrome

Anti-mitochondrial antibodies are associated with __________ .

Primary Biliary Cholangitis

Anti-CCP is an autoantibody used to diagnose __________ .

Rheumatoid Arthritis

c-ANCA($PR3$) is the serologic marker for __________ .

GPA

p-ANCA($MPO$) is associated with __________ and __________ .

MPA, EGPA

Polyarteritis nodosa (PAN) typically spares the __________ .

lungs

EGPA is characterized by the triad of asthma, __________ , and vasculitis.

eosinophilia

The most common type of kidney stone is __________ .

Calcium oxalate

Struvite stones are associated with __________ organisms.

urease-positive

Uric acid stones are unique because they are __________ on imaging.

radiolucent

Cystine stones are identified by their __________ crystals.

hexagonal

In SIADH, both urine osm and urine $Na$ are __________ .

high

Hypovolemic hyponatremia is managed by giving __________ saline.

isotonic

The treatment for symptomatic severe hyponatremia is __________ saline.

hypertonic