MOD 6: Micro - Natural Sources of Antibiotics and Antifungals MOA

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Last updated 4:58 AM on 8/17/26
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26 Terms

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Penicillins

Penicillium chrysogenum

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Cephalosporins

Cephalosporiu spp.

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Aztreonam

Chromobacterium violacaeum

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Thienamycin

Streptomyces cattleya

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Teicoplanin

Actinoplanes teichomyceticus

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Vancomycin

Streptomyces orientalis

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Bacitracin

Bacillus subtilis

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Polymyxin

Bacillus polymyxa

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Chlortetracycline

Streptomyces aureofaciens

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Gentamicin

Micromonospora purpurea

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Neomycin

Streptomyces fradiae

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Streptomycin

Streptomyces griseus

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Chloramphenicol

Streptomyces venezuelae

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Clindamycin

Streptomyces lincolnensis

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Rifampicin

Streptomyces mediterranei

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Amphotericin B

Streptomyces nodosus

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Nystatin

Streptomyces noursei

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Griseofulvin

Penicillium griseofulvum

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Allylamines (Terbinafine, Naftifine)

This antifungal inhibits Squalene Epoxidase

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Azoles (Clotrimazole, Ketoconazole)

These antifungals inhibits Lanosterol-14 alpha-demethylase

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Echinocandin (Micafungin, Caspofungin)

This antifungal inhibits 1,3-beta-D-glucan synthase

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Polyene antifungals (Nystatin,Natamycin, Amphotericin B)

These antifungals creates PORES in the fungal cell membrane

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Griseofulvin

This antifungal disrupts mitotic spindle

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Flucytosine (5-FU)

A prodrug antifungal that inhibits nucleic acid synthesis in its active form

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Tacrolimus (Immunosuppressant, not antibiotic)

Streptomyces tsukubensis

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Kanamycin

Streptomyces kanamyceticus