Blood Bank SPECIFIC Antibody STRUCTURE & FUNCTION

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Last updated 12:38 AM on 9/10/26
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22 Terms

1
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Which is the MOST ABUNDANT antibody class in humans?

IgG

2
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What is the half-life of IgG?

23 days

3
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What is the structure of an IgG (IgG1)?

MONOMER

Classic antibody look

<p>MONOMER </p><p>Classic antibody look </p>
4
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What are the 4 subclasses for IgG and what is their main differences?

IgG1 (66%) MOST COMMON

IgG2

IgG3 (LONG)

IgG4

They differ in constant region AND amount of disulfide bridges

<p>IgG1 (66%) MOST COMMON </p><p>IgG2</p><p>IgG3 (LONG)</p><p>IgG4</p><p>They differ in <mark data-color="#dac603" style="background-color: rgb(218, 198, 3); color: inherit;">constant region</mark> AND amount of disulfide bridges</p>
5
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Which is the ONLY antibody that can CROSS the PLACENTA

IgG

IgG1, IgG3, and IgG4

6
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What are the major functions of IgG?

PRECIPITATION

Complement Activation

Enhances PHAGOCYTOSIS

Neutralization of viruses and bacterial toxins


7
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What is the half life of IgM (MACROglobulin)?

6 days

8
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Which is the FIRST immunoglobulin that is produced in response to an antigen & in newborns?

IgM (MACROglobulin)

remember it’s the first thing that is coded

9
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What are the two forms of IgM and where are they found?

1. Monomer - found on B cell surfaces

2. PENTAMER - found in blood


10
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What is the IgM PENTAMER structure

Made up of 5 MONOMERS

so it has 10 BINDING SITES

11
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What holds the IgM Pentamer together?

J chain

12
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What are the major functions of IgM?

1. BEST complementation

2. AGGLUTINATION

3. PRIMARY RESPONSE

4. Neutralization


13
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What are the two subclasses for IgA and what are their structures?

IgA1 = MONOMER - Serum

IgA2 = DIMER - Secretory

DIMER is HELD TOGETHER by a J chain

<p>IgA1 = MONOMER - Serum </p><p>IgA2 = DIMER - Secretory </p><p>DIMER is HELD TOGETHER by a J chain </p>
14
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What is the function of IgA1?

ANTI inflammatory

15
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What is the function of IgA2 (Secretory IgA)

TRANSPORT

Protection of MUCOSAL surfaces from enzymatic breakdown

16
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What are the Major functions of IgA?

First line of defense at MUCOSAL surfaces

PASSIVELY obtained via BREASTFEEDING

Opsonin like behavior

17
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Which immunoglobulin is VERY SCARCE in serum?

IgD

18
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What is the function of IgD?

Monomer

19
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Where is IgD found/ what function does it serve?

On UNSTIMULATED B cells

MAY function in B CELL ACTIVATION

20
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What is the structure of an IgE?

Monomer

21
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What are the main functions of IgE

remember drama quEEn

Allergic reactions and parasite killing

22
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How does IgE aid in Allergic Reactions?

1. Antigen + IgE on mast cell

2. Causing degranulation of mast cells

3. Release of HISTAMINE + HERPARIN

4. type 1 sensitivity