b6

chemical forms of b6

PLP, PL, PA

food sources

meat, fish: plp, pmp

plants: pnp, pn-glycoside

digestion absorption etc

plp,pnp etc needs to get dephosphorylated. alkaline phosphatase which is zinc dependent. pn-glycoside by glucosidase

absorption: all passive diffusion

transport: i newly absorped go to liver and get converted to plp. plp bound to albumin goes to tissues

storage: stored in muscles with gyocogen phosphorylase

excreted in urine as 4-PA

metabolic functions and roles

amino acid metabolism, neurotransmitter formation, heme formation, lipid metabolism

nutrient gene interactions

enzyme cystathione betasynthase requires b6. some defected ppl have lower enzyme activity. they have 10 fold higher plasma homocysteine

b6 deficiency

neurologic and dermatologic symptoms, microcytic anemia, inflammation, elevated homocysteine