3.19.25 lecture: Prolactin

prolactin is abbreviated _____________

PRL

PRL is a _______________ based hormone produce, produced in the __________________, under control of the ____________________

amino acid; anterior pituitary; hypothalamus

what is the target of PRL?

mammary glands

What makes the regulation of PRL so strange?

it's controlled by an inhibitory hypothalamic hormone

what is the hypothalamic hormone that regulates PRL?

prolactin inhibiting hormone (PIH)

prolactin inhibiting hormone (PIH) is just _________________

dopamine

______________________ secretes PIH into the _____________________ which carries the PIH down to the ______________________ where it will _________________________

hypothalamus; hypophyseal portal system; anterior pituitary; inhibit the secretion of prolactin

True/false: the default for the anterior pituitary cells to always release PRL

true, we have to tell it to stop! this is atypical

suckling on nipple ____________________ which allows anterior pituitary to secrete prolactin into the ______________________, to the mammary glands to produce milk

inhibits PIH; hypophyseal portal system

______________ can also inhibit PIH and acts on the cells in the anterior pituitary to inhibit PIH

estrogen

why do women report breast tenderness during the luteal phase?

high estrogen levels trigger the release of PRL

overproduction of PRL in women:

weaning in children

overproduction of PRL in men:

impotency