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uterus & pregnancy
-increased E&P→growth in 1st trimester d/t increased vascularity, hyperplasia, hypertrophy, decidua development
-increased weight & volume
-more spherical/globular, rises into abdominal cavity (12 weeks)
-visible at week 14
-widens/shortens week 38-40 (“lightening”)
-lower softening (Hegar sign) at week 6→anteflexion→urine frequency
-Braxton HIcks→increased blood flow (4 mo)
-uterine and funic souffle (bruit)
-10x more blood flow
-ballottement: fetus passive movement at weeks 16-18 (via examiner palpation)
-quickening: fetal movement at weeks 14-18+
cervix during pregnancy
-becomes firm & closed, velvety, friable
-soft, elastic, dilated for labor
-softens at tip at week 6 (Goodell sign; indicator of pregnancy)
-mucous plug (operculum) has Ig
ovaries during pregnancy
-ovulation stops d/t decreased FSH & LH (d/t increased E&P)
-E&P made by corpus luteum till week 6-10, then placenta takes over production
vagina & vulva during pregnancy
-thicker mucosa, looser CT, hypertrophy of muscles, lengthens
-increased vascularity
—appears blue at 6-8 weeks = Chadwick sign
—increased sexual arousal in 2nd trimester
—increased edema & varicosities
-increased discharge (white or gray & musty)
-microbiome & pH changes
—increased Candidiasis
breasts during pregnancy
-fullness, increased sensitivity, heaviness, possible tingling or pain
-nipples & areolas: increased size/erection/pigment
-increased blood vessel visibility
-striae gravidarum
-estrogen stimulates lactiferous duct growth
-progesterone stimulates mammary lobe development
-prolactin→colostrum towards end of 1st trimester
—secreted in 2nd trimester
CVS & pregnancy
-BV increases 40-50%, peaks to 1200-1600 mL at week 32 (to meet uterus needs, hydrate, create reserve)
-CO increases 30-50%, peaks at week 25-30 (helps meet O2 need)
-HR increases 10-20 bpm
-DBP decreases till 24-32 weeks, then returns
—supine hTN syndrome from compressed vena cava→CO drops 30 mmHg
-cardiac hypertrophy, moves up & left (PMI rises 1-1.5 cm)
-S1 & S2 split, S3 heard, murmurs over left sternal border
-RBCs increase 20-30% (physiologic anemia)
—anemic = Hgb <11 or Hct <33% (T1); Hgb <10.5 or Hct <32% (T2)
-WBC increases from 2 mo to second or third trimester (not lymphocytes)
-5-6x more TE problems d/t more clot factors
BP in pregnancy
CO = SV x HR (all increase during pregnancy)
BP = CO x PR/SVR
-CO increases
-BP does not increase because PR decreases (d/t vasodilation from progesterone)
respiratory system & pregnancy
-O2 intake increases 40%
-diaphragm moves up 4 cm, costal angle decreases, ribs flare, ligaments relax, transverse diameter increases 2 cm
-TLC does not change, TV increases 40%
-chronic mild hyperventilation
-more chest breathing
-dyspnea
-estrogen→edema & hyperemia in URT (→stuffy nose, epistaxis, voice change, infections, impaired hearing)
GI tract in pregnancy
-gums become hyperemic, spongy, swollen, and bleed
—epulis (nodule) may form at 3 months; prevent with soft brush
-ptyalism
-decreased muscle tone/motility→reflux & heartburn, slower emptying, reverse peristalsis
-increased chance of hernia
-constipation
-gallbladder: distends, increases empty time, thicker bile, higher cholesterol (increased gallstones)
GI problems in pregnancy
N/V
-d/t increased hCG, prostaglandin, gastric dysrhythmia, psychological factors
-usually from week 4 to end of T1
discomfort
-d/t pelvic pressure, ligament tension, flatulence, distention, cramping, uterine contraction
appendix moves up & right
pica
urinary system in pregnancy
-larger & more relaxed kidneys/ureters
-urine rate decreases→lag between urine formation & reaching bladder
-irritable bladder, nocturia, frequency, urgency (early and towards end)
-GFR increases 50%→low CRT/BUN/uric acid
-body water increases 6.5-8.5 L
-increased tubular reabsorption
-increased H2O excretion→thirst
-leg edema
-glucosuria somewhat normal
-proteinuria is a sign of preeclampsia
skin & pregnancy
-hyperpigmentation of nipples/axillae/vulva at 16 weeks
-melasma/chloasma = blotchy brown over face after week 16
-linea nigra
-angiomatas = vascular spiders, arterioles on upper body from month 2-5
-palmar erythema
-possible itch, acne changes, thin/soft nails, hirsutism
-striae gravidarum do not disappear with time
female hormones in pregnancy
-hCG from ovum & chorionic villi maintains E&P production
-progesterone from corpus luteum, then placenta
—stops FSH & LH
—relaxes smooth muscles & decreases uterine contractility
—fat deposit, decreased insulin use
-estrogen from corpus luteum, then placenta
—stops FSH & LH
—fat deposit, decreased insulin use
—genital/uterine/breast enlargement
—increases vascularity
—interferes with folic acid metabolism
—increases proteins
—retains sodium & water
—decreases HCl & pepsin
other hormones in pregnancy
-prolactin from anterior pituitary prepares breasts for lactation
-oxytocin from posterior pituitary
—stimulates uterine contractions
—stimulates milk ejection
-hCS from placenta
—acts as GH
—develops breasts
—decreases glucose metabolism, increases fatty acids
-thyroid hormones support maternal metabolism and fetal growth
-parathyroid hormone controls Ca2+ & Mg2+ metabolism
-more insulin produced to compensate for antagonists
-cortisol from adrenals
—stimulates insulin production
—increases resistance to insulin
-aldosterone from adrenals causes renal sodium reabsorption
musculoskeletal & pregnancy
-pelvis tilts forward
-lordosis, anterior head flexion→UE aching/numbness/weakness
-back pain, leg cramps
-pubis widens at 28-32 weeks
-ab muscles stretch & tone decreases
-rectus abdominal muscles separate (T3)
-relaxed d/t progesterone
-educate on good posture
CNS/PNS in pregnancy
-headache
-lightheaded, syncope
-fatigue T1, insomnia T2-T3
-thicker cornea, decreased IOP, corneal changes
-increased smell/sensation
-carpal tunnel (T3)
endocrine system in pregnancy
-thyroid: increased TH & BMR (25%), maternal thyroxine develops fetal CNS
-pituitary: increased size, more prolactin, ACTH & cortisol decrease then increase
-pregnancy hormones antagonize insulin, pancreas makes more insulin
immune system in pregnancy
-increases, then decreases
-T1 = proinflammatory, T2 = antiinflammatory, T3 = proinflammatory
signs of pregnancy
-possible = mom is having symptoms
-probable = HCP can detect signs (e.g. urine test)
-positive = fetal evidence
trimesters
1st = 0-13 6/7 weeks
2nd = 14-27 6/7
3rd = 28-40 6/7
dx of pregnancy
-hCG = earliest (implantation)
—detectable 7-8 days before missed period
—serum or urine
—too early could→false negative
-ELISA
—OTC, at-home
—urine
—too early→false negative
-anticonvulsants & tranquilizers→false positive
-diuretics & promethazine→false negative
-tumors interfere
EDB
estimated day of birth
-Nagele’s rule = LMP minus 3 mo plus 7 days plus 1 yr
—or add 9 mo and 7 days to LMP
—usually, birth will be w/in 7 days of EDB
process of accepting pregnancy
mom:
1) accept fact of pregnancy
2) accept fetus as distinct from self (5 mo)
3) preps for child & acknowledges motherhood
dad:
1) announcement (accept fact of pregnancy)
2) moratorium (accept reality of pregnancy)
-possible rivalry between infant and wife, need to reorder personal relationships
3) focusing (find his role)
when to have prenatal visits
-initial visit during T1
-monthly till 28 weeks
-every 2 weeks till 36 weeks
-weekly till birth
*less if low-risk
first prenatal visit
-should be before 10 weeks
-interview
-physical exam by HCP
-tests: urine, cervical, blood (blood type, Rh, RBC Ab, CBC, rubella, varicella, STIs)
first prenatal interview
-current S/S
-coping, desire for pregnancy
-menarche age, menstrual hx, contraception, reproductive health, infertility, sexual hx, OB hx
-last LMP date
-health hx
-med use, vax, supplements, substance use
-nutrition
-fam hx
-social/cultural/economic/occupational hx
-mental hx/screening
-IPV/DV (every visit)
-ROS
OB terms
-gravida = woman who is pregnant
-gravidity = pregnancy
-nulligravida = never been pregnant
-primigravida = 1st time pregnant
-multigravida = 2+ time pregnant
-parity = number of pregnancy that reached 20 weeks
-nullipara = never completed pregnancy
-primipara = completed one pregnancy
-multipara = completed 2+ pregnancies
term definitions for pregnancy
preterm = pregnancy ends at 20-36 6/7 weeks
-late preterm = pregnancy reaches 34-36 6/7 weeks
term = 37-41 6/7 weeks
-early term = 37-38
-full term = 39-40
-late = 41
postterm = 42+
document OB hx
G - # of pregnancies (including current)
T - # that reached 20+ weeks
P - # that ended in birth between 20-36 weeks 6 days (preterm)
A - # of abortions before 20 weeks/under 500 g
L - # of living children
*e.g. G4 P2 P0 A1 L2 or G4 P2012
*P for para = # that reached 20+ weeks
follow-up prenatal visits
-brief interview
-physical assessment
-fundal height
-fetal assessment (GA, US, FHTs, movement)
-tests
-genetic screening
-education
fundal height
-measure beginning in T2
-should be equal to GW (±2)from 18-30 weeks
—if bladder is empty
-too low = IUGR, too high = polyhydramnios or multiple babies
-method:
—mom lays supine with pillow under head and wedge one hip
—measure with tape from upper symphysis pubis to upper fundus…
tests at prenatal visits
-urine each time
-Hgb & Hct at 28-32 weeks
-Ab at 28 weeks if mom is Rh-
-GDM at 24-28 weeks
-cultures for strep B (GBS) at 36-37 week
-cfDNA at 10+ weeks (amniocentesis)
-genetic screens 11-14 weeks
-US 18-22 weeks
prenatal education
-travel
—avoid after viability, no planes after 36 weeks
—not to places with bad water or Zika/malaria
—avoid long plane/car ride (DVT risk)
-vax (no live; Tdap, hep B, and flu are okay)
-Rh
—if mom is negative and baby is positive, will need Rx for HDFN (Rh Ig at 26-30 weeks, then 72 hours PP)
-hygiene (sweat will increase)
-UTIs: S/S & prevention
—drink 2.5 L/day
-expected changes
-nutrition
-physical activity (150 min moderate per week)
-posture (lateral recumbent is best when sleeping)
-rest
-meds & vitamins
-substance use
-Kegel exercises
-oral health (risk for gum issues)
-clothing
-job & safety
-breastfeeding (clean with warm water only)
-sexuality
S/S in pregnancy to report immediately
-vaginal bleeding
-RUQ pain w/ HA
-gush of fluid (membrane rupture)
-no fetal movement for 30 min
-severe abdominal pain
most important vitamin in pregnancy
folate (B9)
-deficit causes NTDs
-need 400 mcg/day supplemented
—4 mg/day if hx of NTD
—start taking 1 month before conception
-food sources: liver, legumes, asparagus, spinach, papaya, cereal, broccoli, beans, avocado, orange, pasta, rice, bread, egg, corn
weight gain in pregnancy
-need more nutrients to support fetal growth, tissue growth, increase in TBV, mammary development, & increased BMR
-should gain:
—25-35 lb if normal BMI (2-3 lb/wk in T1, then 1 lb/wk)
—28-40 if underweight
—15-25 if overweight (0.6 lb/wk)
—11-20 if obese (0.5 lb/wk)
-over 6.6 lb in 1 month causes preeclampsia risk
obesity in pregnancy
increased risk of GDM, HTN, assisted or Cesarean birth, SSI, VTE, depression
macro needs in pregnancy
-kcal:
—340 more kcal in T2
—452 more in T3
-fat:
—20-35% of daily kcal
—avoid trans fats
—need 300 mg DHA, AA, omega-3
-carbs:
—175 g/day, 45-64%
—25-35 g fiber
-also need iron supplement
—27 mg/day
—allows increase in TBV
—take with vitamin C or citrus foods
-avoid fat-soluble vitamin supplements
F&E needs in pregnancy
-8-12 cups water/day
—prevents preterm labor
—also milk or decaf tea
-foods supply 700 mL
-sodium <2300 mg
—do not over-restrict (peripheral edema is usually normal)
-need potassium (8-10 servings fruit & veggies)
-under 200 mg caffeine
-avoid aspartame if pt has PAH deficiency
managing N/V in pregnancy
-dry starchy foods
-less fluid in morning
-eat q2-3h, small amounts at a time
-do not skip meals
-move/get up slowly
-fresh air
-cool, non-smelly foods
-avoid spicy or strong flavors
-do not brush teeth right after eating
-salty or tart foods help, herbal tea, ginger
-motion sickness wristbands
-meds or vitamin B6