NSG 116 Drug Therapy for Peptic Ulcer Disease and Hyperacidity

Ulcers can

Bleed and lead to infection and perforation

Interventions for GERD

Elevate bed

Place pillow under your head

Wait 2-3 hrs after eating to go to bed

Simethicone is a

Anti flatulence drug

Parietal cells produce and secrete

Hydrochloric acid(HCL )

Pepsinogen becomes pepsin when exposed to

Acid

Chief cells secrete

Pepsinogen which is a pro enzyme

Parietal cells are the primary

Site of action for many of the drugs used to treat acid-related disorders

The cells of the gastric gland are the largest in

Number and of primary importance when discussing acid control

When taken with warfarin , PPI’s

Increase the chance of GI bleed because it increases the effectiveness of warfarin leading to blood thinn

Misoprostol( cytotec)

Can be used to induce abortions/ miscarriage and is absorbed through skin

PPIs end in

Prazole

Omeprazole is available

Iv or PO

If they chew the antacids it should be given in

IV push or liquid

Sodium alignate must be taken at

bedtime and before every meal

Histamine and acetylcholine triggers proton pumps in the parietal cell to secrete

Hydrochloric acid

PPIs are

How do reflux medications work

What are PPIS

Proton pump inhibitors

We give H2 receptor antagonist After dialysis because you are just

Filtering it out

Histamines act in the

Parietal cell to increase hydrochloric acid

H2 receptor antagonist are used for

GERD

peptic ulcer disease

Gi bleeding from stress ulcer

Prophylactic treat for stress ulcers

H2 antigonis (histamine) end in

Tidine

Decrease calcium if patient has

Calcium stones

Kidney stones come in various sizes

Small or big and causes scrapes and bleeding

Kidney stones cause

Urinary retention. Pain, bleeding

Nephrotoxic

Kills kidneys

Antacids reduce the

Ability of the other drug to be absorbed into the body

A patient who has renal issues should not take which antacid combinations

Calcium containing or magnesium containing antacid because of risk of toxicity and urine retention

Calcium causes

Kidney stones

Therapeutic effects of the drugs

No burning or pain

A patient who has renal issues should take which antacid combination for occasional heartburn

Aluminum containing acids

Antacids should be given

2 hours after another drug or 1 hour before you give the drug

The priority med should be

Administered before you administer the anti acid (I.e hypertension medication first )

Acidic

Below 1.5

Ph higher than the normal prevents

The pepsinogen converting to pepsin

Antacid onset

20-60 minutes for relief of pain

Above 1.5

More basic

Antacids decrease what’s already

In the stomach

Cells of

Prilosec, omprezole, and protonix is given commonplace in the hospital

As a prophylactic treatment for prevention of stress ulcers

NSAiDs can cause

ulcers and excessive bleeding

Renal patients should not take this combo antacid