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Drugs in class
Sacubitril/valsartan (Entresto)
Properties/MOA
· Keeps natriuretic peptides from being broken down which helps decrease preload
ARB’s decrease afterload via decreasing angiotensin and decrease preload via decreasing aldosterone
Effects/Adverse Rxn
· Hypotension
· Dizziness
· Increased K+
· Weakness
Diarrhea
Contraindications
· Severe hepatic impairment
· Biliary cirrhosis
Don’t use with ACE inhibitors
Nursing Info.
· Check BP
Check K+