Escherichia Coli

Gram - rods

Facultative anaerobes

Non-spore forming

Motile

Escherichia Coli is what kind of bacteria?

Provide vit K and B12

Exclude pathogens

What do Mutualist E. coli do for the gut microbiome?

Pathotypes

Pathogenic E. coli will be catogorized how?

Enterotoxigenic

Enteropathogenic

Siga toxin producing

What are the three Enteric pathotypes of E. coli?

Avian pathogenic

Systemic

Uropathogenic

What are three extra intestinal pathotypes of E. coli?

Fibril adhesions

What kind of adhesions do pathogenic E. coli have?

Enterocyte hypersecretion and malabsorption

What will enterotoxins do?

Damage enterocytes and endothelial cells

What will Shiga toxins do?

Extra-intestinal pathotypes

What will cytotoxins be secreted by?

Pyrogenic

Damage endothelium

Activate coagulation cascade

What will E. coli endotoxins do?

Over crowding/ poor hygiene

Insufficient colostrum/ immune system

Stress

What will typically predispose an animal to E. coli infection? /

VERY young - piglets, Calves, Lambs

Enterotoxigenic (ETEC) will be most common in what animals?

Jejunum and ileum

What will ETEC affect in the body?

Diarrhea (Watery to pasty)

Dehydration

Acidosis

What are symptoms of ETEC?

Ileum and colon - maldigestion/ absorption diarrhea

Enteropathogenic E. coli (EPEC) will affect what region of the intestines?

ETEC - 1-2 w post weaning

What type of E. coli is indicated for post weaned Diarrhea in pigs?

Reduced feed intake,

Watery diarrhea

What are mild cases of post weaned Diarrhea in pigs?

Profuse watery diarrhea

Bluish- red skin

Sudden death

What are severe cases of post weaned Diarrhea in pigs?

Edema dz in swine

Shiga toxin production E. coli (STEC) will cause what in swine?

Shiga toxin (ST2e) will enter blood stream via damage of endothelial cells in the SI and lead to perivascular edema

What is the pathogenesis of STEC?

Periocular edema

Swelling of forehead/ submandibular reason

Dysnea

Hoarse squeal

Anorexia

Muscular tremors

Ataxia

Posterior paresis

What are clinical signs of STEC?

Flaccid paralysis

What will proceed death in STEC infections?

CNS dysfunctions

Survivors of STEC will typically have what?

SQ and stomach edema

Mesocolon

What are gross lesions of STEC?

Newborn ruminants

Septicemic E. coli (SEPEC) is most common in what animals?

Infected naval

Cross nasal/ oral mucosa

SEPEC will be infective how?

Sudden death

Lack of suckling

Weakness

Diarrhea

Resp dz

Menengitis

Polyarthritis

What are clinical signs of SEPEC?

Feces

urine

oral and nasal secretions

SEPEC infected animal will excreat the bacteria where?

Breach of resp mucosa via inhalation of aerosolized dried feces

How is avian pathogenic E. coli (APEC) transmitted?

Acute septicemia and sudden death - few to no clinical signs prior to death

What are signs of APEC?

Fibrinopurulent lesions of internal organs, serosae and joints - decreased production

What might be seen in surviving birds w/ APEC?

Dogs/ Cats urinary and repro tracts

What does Uropathogenic E. coli (UPEC) affect?

Cystitis

Pyelonephritis

Pyometra

Canine prostasitis

What does UPEC cause?

No pathotype - fecal contamination of mammary gland

What will cause Coliform mastitis?

Rapid growth in udder

Endotoxin

Local inflammation and systemic illness

What is the pathogenesis of coliform mastitis?

Swollen quarters - watery/ serious secretion w/ flakes

- high rate of spontaneous cure

Moderate coliform mastitis will have what clinical signs?

ABX

Supportive care

(Culture as needed and potential sx)

What is typically tx for E. coli?

Change gradually

High fiber low protein (Edema dz)

Zinc oxide (Post weaning diarrhea)

What are some dietary changes for E. coli prevention?

Vax

There are __ available for E. coli?