chapter 3 immunology - BCR vs. TCR & High-Yield Integration

Can a BCR bind free antigen?

Yes.

Can a TCR bind free antigen?

No.

What must antigen be associated with for a TCR to recognize it?

MHC.

What recognizes antigen in the BCR complex?

Membrane immunoglobulin.

What signals in the BCR complex?

Igα and Igβ.

What recognizes antigen in the TCR complex?

TCR.

What signals in the TCR complex?

CD3.

Do both BCRs and TCRs contain immunoglobulin domains?

Yes.

Do both BCRs and TCRs contain variable and constant regions?

Yes.

Do both BCRs and TCRs use CDRs for specificity?

Yes.

What signaling motif is used by both BCR and TCR complexes?

ITAM.

BCR structure?

Two heavy chains + two light chains.

TCR structure?

Usually one α chain + one β chain.

BCR antigen recognition?

Directly binds antigen.

TCR antigen recognition?

Binds peptide-MHC.

Low Kd = ?

High affinity.

High Kd = ?

Low affinity.

Strength of one receptor-ligand interaction = ?

Affinity.

Collective strength of multiple interactions = ?

Avidity.

What does receptor clustering enhance?

Signal transduction.

What do adaptor proteins provide?

A signaling scaffold.

What is a common early event in immune receptor signaling?

Tyrosine phosphorylation.

What is a common final result of immune receptor signaling?

Altered gene expression.

Autocrine = ?

Same cell.

Paracrine = ?

Nearby cells.

Endocrine = ?

Distant cells through blood.

Chemokine = ?

Cytokine that directs leukocyte migration.

CD4 = which MHC?

MHC II.

CD8 = which MHC?

MHC I.

Endogenous antigen = which MHC?

MHC I.

Exogenous antigen = which MHC?

MHC II.

MHC I = which T cell?

CD8 T cell.

MHC II = which T cell?

CD4 T cell.

Primary T-cell signal = ?

TCR + peptide-MHC.

Activating secondary T-cell signal = ?

CD28 + CD80/CD86.

BCR signaling proteins = ?

Igα and Igβ.

TCR signaling complex = ?

CD3.