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Where do T-lymphocytes originate from?
Red bone marrow
What are the T-lymphocytes called when they’re at the red bone marrow?
Pre-T-Lymphocytes
Another name for Pre-T-Lymphocytes?
Thymocytes
Do pre-T-lymphocytes have TCR, CD4, and CD8 proteins?
False.
Pre-T lymphocytes only have TCR, but no CD4 and CD8 proteins
After leaving the red bone marrow, where do the pre-T-lymphocytes travel to?
Thymus gland
What happens to the thymocytes once they travel to the thymus gland?
They’re still immature, but now develops CD4 and CD8 proteins
What are the two thymic selection that T-lymphocytes must go through?
Positive and Negative selection
What is the last thymic selection that 2% of the T-lymphocytes go through?
Differentiation
The selection with the ability of a T-lymphocyte to bind to thymic epithelial cells to either class of MHC molecules (that present “foreign” antigens) is called…
Positive selection
The selection where the TCR of these thymocytes binds to a self-antigen is called…
Negative selection
Where does positive selection occur?
Thymus cortex
Where does negative selection occur?
Thymus cortex (+ primary lymphatic structures)
If 2% of the T-cells survived, how are the 98% eliminated?
Apoptosis
Can a single T-lymphocyte possess both CD4 and CD8 proteins?
NO! One can only carry one CD molecule
After passing the test, what happens to the T-lymphocytes?
They mature, moving to secondary lymphatic structures and are still NAIVE
