Omega-3-acid ethyl esters

Omega-3-acid ethyl esters

Lovaza

Omega-3-acid ethyl esters drug class

Antihyperlipidemic, Omega-3 Fatty Acids

Omega-3-acid ethyl esters dosage form

oral: DR capsule, liquid filled capsule

Omega-3-acid ethyl esters ON label indication

Hypertriglyceridemia, adjunct to diet in adults with triglyceride levels 500 mg/dL or higher

Omega-3-acid ethyl esters OFF label indication

1. Coronary arteriosclerosis, hypertriglyceridemia

2. IgA nephropathy

Omega-3-acid ethyl esters MOA

Potential mechanisms of action include inhibition of acyl-CoA:1,2-diacylglycerol acyltransferase, increased mitochondrial and peroxisomal β-oxidation in the liver, decreased lipogenesis in the liver, and increased plasma lipoprotein lipase activity. Lovaza may reduce the synthesis of triglycerides in the liver because eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are poor substrates for the enzymes responsible for TG synthesis, and EPA and DHA inhibit esterification of other fatty acids

Omega-3-acid ethyl esters box warning

none

Omega-3-acid ethyl esters contraindication

Hypersensitivity to omega-3-acid ethyl esters, fish, or shellfish

Omega-3-acid ethyl esters pregnancy/breastfeeding

compatible/compatible

Omega-3-acid ethyl esters adverse effects

Diarrhea